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SOD2 — TFAP2A

Text-mined interactions from Literome

Zhu et al., J Biol Chem 2001 : To examine the functional role of AP-2 on Mn-SOD promoter transactivation we cotransfected AP-2-deficient HepG2 cells with a human Mn-SOD promoter-reporter construct and expression vectors encoding each of the three known AP-2 family members ... Our results indicated that AP-2 could significantly repress Mn-SOD promoter activity, and that this repression was both Mn-SOD promoter and AP-2-specific ... Repression of Mn-SOD by AP-2 was dependent on DNA binding, and expression of AP-2B, a dominant negative incapable of DNA binding, relieved the repression on Mn-SOD promoter and reactivated Mn-SOD expression in the AP-2 abundant SV40 transformed fibroblast cell line MRC-5VA ... These results indicate that AP-2 mediated transcriptional repression contributes to the constitutively low expression of Mn-SOD in SV40 transformed fibroblasts and suggest a mechanism for Mn-SOD down-regulation in cancer
Xu et al., Biochem J 2002 (Carcinoma, Hepatocellular...) : These findings, coupled with our previous observation that several cancer cell lines have mutations in the promoter region of the human MnSOD gene, which lead to an increase in an AP-2 binding site and a decrease in the promoter activity, signal the importance of understanding the promoter structure and the regulation of the human SOD2 gene by Sp1 and AP-2