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MMP1 — TNF

Text-mined interactions from Literome

Gallery et al., Microvasc Res 1999 (Pre-Eclampsia...) : Neither tumor necrosis factor-alpha nor transforming growth factor-beta, both thought to have significant roles in the control of placentation, affected MMP secretion
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF) , interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Watari et al., Am J Pathol 1999 : TNF-alpha induced cathepsin S, MMP-1 , -3, and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml, with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml ... TNF-alpha induced cathepsin S, MMP-1 , -3, and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml, with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml
Conant et al., Ann Neurol 1999 (AIDS Dementia Complex) : We also examined the possibility that such MMPs could be produced by brain derived cells, and that MMP production by these cells might be increased by tumor necrosis factor-alpha , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD
Nakada-Tsukui et al., J Leukoc Biol 1999 : Although only hydroxamate matrix metalloproteinase ( MMP ) inhibitors inhibited the basal processing and release of TNF-alpha, the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin ( 3,4-DCI ), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK )
Ala-aho et al., Oncogene 2000 (Cell Transformation, Neoplastic) : IFN-gamma abolished the enhancement of MMP-13 and MMP-1 expression by transforming growth factor-beta ( TGF-beta ) and tumor necrosis factor-alpha (TNF-alpha) , and inhibited invasion of A-5 cells through type I collagen
Chambaut-Guérin et al., J Neurochem 2000 (Neuroblastoma) : In contrast, MMP-9 was inducible by RA, TNFalpha , or PMA
Siwik et al., Circ Res 2000 : IL-1beta and TNF-alpha each increased total matrix metalloproteinase ( MMP ) activity as measured by in-gel zymography, causing specific increases in the bands corresponding to MMP-13, MMP-2, and MMP-9
Han et al., J Cell Sci 2001 : To investigate this observation at the cellular and molecular levels, we examined TNF-(alpha) mediated activation of pro-MMP-2, induction of MT1-MMP , and the intracellular signaling pathways that regulate the proteinase in isolated human dermal fibroblasts
Schweyer et al., Virchows Arch 2000 (Gout) : These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes, MMP-2 and MMP-9, suggesting that TNF-alpha may induce MMP production followed by matrix degradation within foreign body granulomas
Sakai et al., J Bone Miner Res 2001 : Furthermore, the inhibitors completely prevented the TNF-alpha dependent induction of MMP-1 , MMP-3, ICAM-1, and COX-2 mRNAs
Lin et al., J Endod 2001 : Northern hybridization showed that IL-1alpha and TNF-alpha induced significant MMP-1 gene expression, with only little effect on TIMP-1 gene ... The differential regulation of IL-1alpha or TNF-alpha induced MMP-1 and TIMP-1 mRNA synthesis, as well as the direct upregulation of TIMP-1 gene expression by PGE2, also implied that prostaglandin may serve as a protective mechanism from excessive tissue breakdown during pulpitis
Baram et al., J Immunol 2001 : MMP-9 release was first detected at 6 h and peaked at 22 h of incubation with activated T cell membranes, while TNF-alpha release peaked after only 6 h. Anti-TNF-alpha mAb inhibited the T cell membrane induced MMP-9 release, indicating a possible autocrine regulation of MMP release by mast cell TNF-alpha
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Majka et al., Invest Ophthalmol Vis Sci 2002 (Retinal Neovascularization) : Isolated RMVECs did not significantly increase MMP production directly in response to a hypoxic stimulus, but required the presence of exogenous TNFalpha ... TNFalpha increased the expression of MT1-MMP , MMP-3, and MMP-9 in these cells
Okuno et al., Scand J Gastroenterol 2002 : IL-1beta and TNF-alpha both induced a dose- and time dependent increase in IL-8, MCP-1 and MMP-1 secretion, and weakly stimulated MMP-2 secretion
Vincenti et al., Arthritis Res 2002 (Arthritis, Rheumatoid...) : Of these enzymes, the expression of MMP-1 and MMP-13 is substantially increased in response to IL-1 and tumor necrosis factor-alpha , and elevated levels of these collagenases are observed in arthritic tissues
Ardans et al., J Leukoc Biol 2002 : However, in the presence of tumor necrosis factor (TNF)-alpha and GM-CSF, ox-LDL enhanced MMP-1 significantly by two- to threefold, increased MMP-9 slightly, and had no effect on TIMP-1 production ... In contrast, HDL suppressed the induction of MMP-1 by TNF-alpha and GM-CSF as well as the ox-LDL mediated increase in MMP-1 production
Nishikawa et al., J Periodontal Res 2002 : This study used reverse transcriptase-PCR to investigate the effects of TNFalpha on matrix metalloproteinase ( MMP ) mRNA expression in human periodontal ligament fibroblasts ... TNFalpha increased MMP-1, MMP-3 and MMP-13 mRNA levels in both a time dependent ( 0-24 h ) and a dose dependent ( 0.1-10 ng/ml ) manner ... TNFalpha increased MMP-1 , MMP-3 and MMP-13 mRNA levels in both a time dependent ( 0-24 h ) and a dose dependent ( 0.1-10 ng/ml ) manner ... Because elevation of COX-2 mRNA levels enhances the production of prostaglandins, we therefore investigated whether endogenous prostaglandins are involved in the MMP mRNA expression that is enhanced by TNFalpha
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : The results showed that gingival fibroblasts constitutively produce MMP-1 and MMP-3, and that the cytokines IL-1beta, TNFalpha and EGF increase both MMP-1 and MMP-3 production in gingival fibroblasts ... In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone ... Our findings demonstrate that the cytokines IL-1beta, TNFalpha and EGF, respectively, enhance both MMP-1 and MMP-3 production in human gingival fibroblasts, and that the signal pathways COX-2, MAP-kinases and tyrosine kinases are partly involved in the production of MMPs
Alexander et al., Invest Ophthalmol Vis Sci 2003 (MAP Kinase Signaling System) : The components of this MAP kinase pathway in the TM are dramatically affected by TNFalpha and inhibition of Erk 's phosphorylation blocks the changes in MMP and TIMP expression
Leonardi et al., Invest Ophthalmol Vis Sci 2003 (Conjunctivitis, Allergic) : Both IL-4 and -13 significantly decreased production of MMP-1 and increased that of TIMP-1, whereas TNF-alpha increased production of MMP-1 and -9
Lin et al., J Bone Miner Res 2003 (Bone Resorption...) : Interestingly, SNAP, a NO donor, although by itself is not a MMP-1 stimulator for UMR-106, augmented the TNF-alpha stimulated MMP-1 mRNA production in UMR-106
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha) , IL-6, HGF, and 12-O-tetradecanoylphorbol 13-acetate
Shimizu et al., J Rheumatol 2003 (Arthritis, Rheumatoid) : Treatment with HA ( 0.3 approximately 3.0 mg/ml ) resulted in a significant decrease in the production of MMP-1 induced by TNF-a and IL-1beta, in a dose dependent manner ... HA of 250 approximately 2300 kDa at 3 mg/ml was found to suppress the induction of MMP-1 by TNF-a
Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4, and TNF-alpha expression
Bamba et al., J Gastroenterol 2003 : In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17, IL-1beta, and TNF-alpha
Wang et al., Cardiovasc Res 2003 : TNF-alpha mediates the stretch induced MMP genes expression, at least in part, through the JNK pathway
Alsalameh et al., J Rheumatol 2003 (Arthritis, Rheumatoid...) : TNF-a stimulation induced IL-6 secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ), as well as MMP-1 secretion ( RA, 85-fold ; OA, 29-fold ), with significant differences between RA and OA
Zhou et al., J Biol Chem 2003 : Tumor necrosis factor-alpha (TNFalpha) and granulocyte macrophage colony stimulating factor ( GM-CSF ) individually enhance monocyte matrix metalloproteinase-9 (MMP-9) but induce MMP-1 only when added in combination ... IFNgamma induced MMP-1 in the presence of GM-CSF through the stimulation of TNFalpha production through a mechanism involving both p38 and ERK1/2 MAPKs, in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated p38
Tasaki et al., Pancreatology 2003 (MAP Kinase Signaling System) : IL-1l and TNF-alpha stimulated the MMP-1 secretion in a dose- and time dependent manner ... In contrast, SB203580 ( p38 MAPK inhibitor ), GF109203X ( PKC inhibitor ), and PDTC ( NF-kappaB inhibitor ) did not alter the MMP-1 secretion induced by IL-1beta and TNF-alpha
Pillinger et al., J Immunol 2003 : IL-1beta and TNF-alpha stimulated FLSC extracellular signal regulated kinase ( ERK ) activation as well as MMP-1 and -13 release
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically, OSM + TNFalpha induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Moon et al., J Cell Physiol 2004 : Finally, the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed TNF-alpha induced ERK activity, MMP-9 production, and promoter activity
Fuchs et al., Osteoarthritis Cartilage 2004 : TNFalpha , IL-1alpha, and IL-1beta led to marked increases in MMP-1 and MMP-3 release ( up to 4.2-fold and 547-fold, respectively ) by synovial fibroblasts, whereas secretion of MMP-13 was induced by concomitant administration of TNFalpha and IL-1beta
Behera et al., Infect Immun 2004 (MAP Kinase Signaling System) : Inhibition of tumor necrosis factor alpha (TNF-alpha) significantly reduced MMP-1 but not MMP-3 expression from B. burgdorferi infected cells ; inhibition of interleukin-1beta (IL-1beta) had no effect ... Treatment of B. burgdorferi infected cells with JAK and MAPK inhibitors significantly inhibited TNF-alpha induction, consistent with at least a partial role for TNF-alpha in B. burgdorferi induced MMP-1 expression in chondrocytes
Meli et al., J Neuroimmunol 2004 (Disease Models, Animal...) : We investigated the pharmacokinetics and the effect of TNF484 , a water-soluble hydroxamate based inhibitor of MMP and TACE, on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis
Rutkauskaite et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : The effects of stimulation with lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFalpha) on the production of MMP-1 were assessed accordingly ... RzMMP-1 not only reduced the spontaneous production of MMP-1, but also prevented the LPS- and TNFalpha induced increase in MMP-1 production
Martin-Chouly et al., Life Sci 2004 : These results suggest that PDE4 inhibitors are effective in inhibiting the pro-MMP-2 and pro-MMP-1 secretion induced by TNF-alpha and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling
Churg et al., Am J Respir Crit Care Med 2004 (Pulmonary Emphysema) : TNF-alpha causes increased MMP production, but some increased MMP activity is present even in TNFRKO mice
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Pillinger et al., J Biol Chem 2005 (Inflammation...) : Tumor necrosis factor (TNF)-alpha , interleukin (IL)-1beta, and epidermal growth factor (EGF) stimulated gastric cell MMP-1 secretion, indicating that MMP-1 secretion occurs in inflammatory as well as non-inflammatory situations
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression ... Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1 , MMP-3, and MMP-13 expression
Bruce et al., Toxicol Appl Pharmacol 2005 (Asthma...) : Tumor necrosis factor alpha (TNFalpha) has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses, and its release can be inhibited by MMP inhibitors
Kim et al., J Lipid Res 2005 : We also found that EPA inhibited 12-O-tetradecanoylphorbol-13-acetate- or tumor necrosis factor-alpha induced MMP-1 expression in HDFs and UV-induced MMP-1 expression in HaCaT cells
Ho et al., Biochem Pharmacol 2005 : We showed that both MMP-1 and MMP-13 mRNA expression, protein production and enzyme activity induced by either IL-1 or TNF-alpha were suppressed by t-RA or different retinoid derivatives
Sundelin et al., Acta Otolaryngol 2005 (Carcinoma, Squamous Cell...) : The objective of this study was to investigate the effects of IL-6, soluble IL-6 receptor ( sIL-6R ), HGF, TNF-a and IL-8 on MMP-1 , -2 and -9 expression by two oral squamous cell carcinoma cell lines ( UT-SCC-20A and -24A ) ... TNF-a stimulated MMP-9 secretion in both cell lines, but only stimulated MMP-1 secretion in one ( UT-SCC-24A )
Shimizu et al., Mediators Inflamm 2005 (Rhinitis, Allergic, Perennial) : We evaluated whether tranilast ( TR ) could inhibit MMP production from nasal fibroblasts in response to tumor necrosis factor-alpha (TNF-alpha) stimulation in vitro
Zhang et al., J Leukoc Biol 2006 (Coronary Artery Disease) : Although CRP or ox-LDL failed to induce MMP-1 in control monocytes, these molecules enhanced MMP-1 production induced by tumor necrosis factor alpha (TNF-alpha) and granulocyte macrophage-colony stimulating factor ( GM-CSF ) with a synergistic increase in MMP-1 occurring in the presence of both mediators
Krueger et al., J Biol Chem 2006 : In vitro, MMP-1 is up-regulated by interleukin-1beta and tumor necrosis factor-alpha , but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies
Sondergaard et al., Osteoarthritis Cartilage 2006 : TNF-alpha and OSM induced a pronounced increase in matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Pei et al., Osteoarthritis Cartilage 2006 (Chondrosarcoma) : IL-1beta and TNFalpha strongly induced the expression of MMP-1 and -13 in SW1353 cells and HACs, whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells
Roy et al., Antioxid Redox Signal 2006 (Inflammation) : Pretreatment of HMECs for 2 days with BE potently prevented TNFalpha induced expression and activity of MMP-3, MMP-10 , and MMP-12
Chung et al., Curr Drug Targets 2006 (Pulmonary Disease, Chronic Obstructive) : TNFalpha and IL-1beta stimulate macrophages to produce matrix metalloproteinase-9 [ MMP-9 ], and bronchial epithelial cells to produce extracellular matrix glycoproteins
Braundmeier et al., Am J Reprod Immunol 2006 (Endometriosis) : TNF-alpha stimulated MMP-1 and -3 protein secretion in a time dependent manner and stimulated MMP-1 , -2 and -3 mRNA levels in a time dependent manner ( P < 0.05 )
Lee et al., Life Sci 2006 : Emodin inhibits TNF alpha induced MMP-1 expression through suppression of activator protein-1 (AP-1) ... In this study, we found that emodin, an anthraquinone which has been isolated from the rhizome of Rheum palmatum, significantly inhibited TNF alpha induced MMP-1 gene expression in a concentration dependent manner ... Therefore, we have attempted to characterize the inhibitory mechanism of emodin in TNF alpha induced MMP-1 expression ... In a consistent result, the TNF alpha induced MMP-1 expression was inhibited by PD98059 ( MEK/ERK inhibitor ) and SP600125 ( JNK inhibitor ), but was not inhibited by SB203580, a p38 MAPK inhibitor ... Taken together, these results show that emodin suppresses TNF alpha induced MMP-1 expression through the inhibition of the AP-1 signaling pathway
Fushimi et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : Prostaglandin E2 downregulates TNF-alpha induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation ... In response to TNF-alpha , MMP-1 is induced and actively released from HCS-2/8 cells ... In response to TNF-alpha , MMP-1 is induced and actively released from HCS-2/8 cells ... In contrast, SB203580, a selective p38 mitogen activated protein kinases ( MAPK ) inhibitor, had no effects on TNF-alpha induced MMP-1 release ... In contrast, blockade of endogenously produced PGE ( 2 ) signaling by ONO-AE3-208, a selective EP4 receptor antagonist, enhanced TNF-alpha induced MMP-1 production ... Taken together, these findings indicate that Raf-1/MEK/ERK signaling pathway plays a crucial role in the production of MMP-1 in HCS-2/8 cells in response to TNF-alpha , and that the produced PGE ( 2 ) downregulates the expression of MMP-1 by blockage of TNF-alpha induced Raf-1 activation through EP4-PGE ( 2 ) receptor activation
Lin et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : To investigate the regulatory effects of fenofibrate on TNF-alpha induced CD40 expression and matrix metalloproteinase ( MMP ) activity in human vascular endothelial cells ( HUVECs )
Inatomi et al., Pancreas 2007 : In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively
Oyama et al., J Periodontal Res 2007 : Roxithromycin inhibits tumor necrosis factor-alpha induced matrix metalloproteinase-1 expression through regulating mitogen activated protein kinase phosphorylation and Ets-1 expression ... In the present study, we examined the effect of roxithromycin on TNF-alpha induced MMP-1 production by HPDL cells ... In HPDL cell cultures, roxithromycin strongly inhibited TNF-alpha induced MMP-1 mRNA expression and production ... Roxithromycin inhibits TNF-alpha mediated MMP-1 induction through the downregulation of ERK1/2 and JNK activation and the subsequent reduction of Ets-1, suggesting that roxithromycin may have therapeutic use in periodontitis and other chronic inflammatory conditions involving MMP-1 induction
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1 : failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis ... The above effects were comparable in RA- and OA-SFB, except that TNFalpha induced MMP-1 secretion was reversed by p38 inhibition only in OA-SFB
Zeni et al., Am J Physiol Cell Physiol 2007 : Moreover, MMP activity in PCPEC supernatants was significantly increased by TNF-alpha , presumably due to a diminished expression of TIMP-3 that was similarly observed
Abeles et al., Arthritis Rheum 2007 (Rheumatic Diseases) : RASFs obtained from patients during elective knee replacement surgery were assessed by immunoblotting and/or enzyme linked immunosorbent assay for secretion of MMP-1 and MMP-13 in the presence of tumor necrosis factor alpha (TNFalpha) , interleukin-1beta (IL-1beta), statins, the farnesyl transferase ( FT ) inhibitor FTI-276 and geranylgeranyl transferase inhibitor GGTI-298, and prenyl substrates ( farnesyl pyrophosphate [ FPP ] and geranylgeranyl pyrophosphate [ GGPP ] )
Yagi et al., J Gastroenterol 2007 (Colitis) : A similar augmentation was also observed in tumor necrosis factor (TNF)-alpha induced cytokine and MMP secretion
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : We hypothesized that IL-1beta and TNF-alpha may induce matrix metalloproteinase (MMP)-1 and MMP-3 activity to promote PTD by degrading decidual and fetal membranes and cervical extracellular matrix ... Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term, idiopathic preterm, and CAM complicated deliveries, and 2 ) the separate and interactive effects of IL-1beta, TNF-alpha , medroxyprogesterone acetate ( MPA ), and a p38 MAPK inhibitor ( SB203580 ) on MMP-1 and MMP-3 expression in term decidual cells (DCs) ... Compared with basal outputs by DCs incubated with E2, TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold, respectively, and IL-1beta increased MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold, respectively ( P < 0.05 )
Gamo et al., J Exp Zool A Ecol Genet Physiol 2007 : The effects of TNF-alpha on proliferation and MMP production of RES have been shown for the first time
Wang et al., World J Gastroenterol 2007 (Colitis, Ulcerative) : MMP-1 promotes secretion of TNF-alpha in a positive feedback manner to cause further injury in the colon mucosa
Michalski et al., Journal of translational medicine 2007 (Chronic Disease...) : LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1
Nah et al., J Pharmacol Sci 2008 (Arthritis, Rheumatoid) : Mellitin had no effect on IL-1beta- or TNF-alpha induced MMP1 or MMP3 production and did not decrease LPS induced secretion of MMP1
Séguin et al., Spine (Phila Pa 1976) 2008 : The effect of TNF-alpha on membrane type (MT)1-MMP , an activator of MMP-2, was also assessed
Kawamura et al., Dig Dis Sci 2009 : Propionate and butyrate significantly attenuated IL-1 beta- and TNF-alpha induced MMP-1 and MMP-3 secretion
Rogliani et al., Respir Med 2008 (Pulmonary Emphysema...) : In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2, MMP-9 , MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha
Müller et al., Cytokine 2008 : TNF-alpha suppressed collagen type II and aggrecan, but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls
Hozawa et al., Liver Int 2008 : This study explored the transcriptional induction of the MMP-1 gene by tumour necrosis factor-alpha (TNF-alpha) in HSCs ... Mutation in a putative nuclear factor (NF)-kappaB binding site at -2541 bp almost completely abolished the TNF-alpha response to MMP-1 gene-promoter activity, suggesting transcriptional regulation of MMP-1 expression by TNF-alpha via this site ... MMP-1 gene expression might be induced by TNF-alpha via the p50/p50 homodimer of NF-kappaB in activated human HSCs
Asano et al., Int J Chron Obstruct Pulmon Dis 2008 : We evaluated whether tiotropium bromide hydrate ( TBH ), a M3 muscarinic receptor antagonist, could inhibit MMP production from lung fibroblasts ( LFs ) in response to tumor necrosis factor (TNF)-alpha stimulation
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : TNF-alpha does not induce MMP expression to the same degree as stimulation by IL-1beta, but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2
Horiuchi et al., J Rheumatol 2009 (Arthritis, Rheumatoid...) : On the other hand, knockdown of HDAC1, but not of HDAC2, upregulated tumor necrosis factor-alpha induced MMP-1 production by RA-SF
Voigt et al., Arthritis Res Ther 2009 : TNFalpha increased matrix metalloproteinase (MMP)-3 and a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS)-4 mRNA expression, whereas collagen type I was decreased, and aggrecan, collagen type II as well as MMP-1 , -2, -13 and ADAMTS-5 were variably affected
Bauer et al., PloS one 2009 (Colitis) : Inhibition of ASM completely abolished the induction of MMP-1 by TNF or IL-1beta in Caco-2-IEC and human intestinal fibroblasts ... Induction of MMP-1 by TNF or IL-1beta is completely blocked by inhibition of ASM with imipramine
Zeldich et al., J Periodontal Res 2010 : In contrast, tumor necrosis factor significantly increased MMP-1 expression, and EMD reduced it when both agents were present
Steenport et al., J Immunol 2009 (Chronic Disease...) : Exposure of macrophages to MMP-1 and MMP-3 triggered the rapid release of TNF-alpha , which was blocked by MMP inhibitors
Awad et al., Am J Physiol Cell Physiol 2010 (Cardiomyopathies...) : We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since TNF induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma
Murray et al., J Mol Cell Cardiol 2010 : While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha, however, matrix metalloproteinase ( MMP ) activation of TNF-alpha may also be contributory
Lee et al., J Immunol 2010 : Notably, MMP-8 inhibitor suppressed TNF-alpha production more efficaciously than MMP-3 or MMP-9 inhibitors
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : MMP inhibitors, such as doxycycline, minocycline, and batimastat, significantly reduced the cerebral infarct size, and the expressions of monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-a (TNF-a) , and indoleamine 2,3-dioxygenase (IDO)
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1 , MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Moon et al., Osteoarthritis Cartilage 2013 (Osteoarthritis, Knee) : Resveratrol dose-dependently inhibited TNF-a induced cyclooxygenase-2 (COX-2), MMP-1 , MMP-3, MMP-13 and PGE ( 2 ) production in human chondrocytes
Bailey et al., PloS one 2012 (Crohn Disease...) : Fibroblasts from intestinal muscle expressed Ra1, phosphorylated STAT6 in response to IL-13, and subsequently down-regulated MMP-2 and TNF-a induced MMP-1 and MMP-9 synthesis
Yamada et al., Biochem Pharmacol 2013 : The expression of MMP-1, MMP-3 , and MMP-9 increased in the presence of TNF-a , and the addition of infliximab reversed the increase ... The expression of MMP-1 , MMP-3, and MMP-9 increased in the presence of TNF-a , and the addition of infliximab reversed the increase ... Furthermore, infliximab effectively attenuated the TNF-a induced increases in MMP expression in cells that make up the BAB
Cornelius et al., J Invest Dermatol 1995 (Neovascularization, Pathologic) : Northern hybridization assays showed pretranslational control of PMA-, basic fibroblast growth factor-, and TNF-alpha induced MMP expression
Panagakos et al., Inflammation 1995 (Osteosarcoma) : TNF-alpha enhances MMP-1 transcription nearly 12-fold initially, after which mRNA levels drop off but remain significantly higher than the controls
Gearing et al., J Leukoc Biol 1995 : MMP inhibitors prevent the rise in blood levels of TNF after endotoxin administration in rats and are effective in animal models of inflammatory disease such as adjuvant arthritis
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner
Ries et al., Blood 1994 (Leukemia, Promyelocytic, Acute) : Thus, MMP-9 secretion may be regulated by TNF-alpha not only in a paracrine but also in an autocrine fashion
Hanemaaijer et al., Biochem J 1993 : On the other hand, MMP-2 and TIMP-2 were not affected or were affected in a variable way by TNF alpha and/or phorbol ester, suggesting a dissimilar regulation of these proteins
Migita et al., Immunology 1996 (Arthritis, Rheumatoid) : In support of this result, TNF-alpha stimulation induced membrane-type matrix metalloproteinase ( MT-MMP ), a newly identified MMP-2-specific activator on synovial fibroblasts ... Cycloheximide analysis demonstrated that protein synthesis may be required for TNF-alpha mediated MT-MMP expression on synovial fibroblasts
Barillé et al., Blood 1997 (Multiple Myeloma) : Whereas MMP-1 is positively regulated by IL-1beta, tumor necrosis factor-alpha , and Oncostatin M, MMP-2 is not modulated by any of these cytokines
Yang et al., J Biol Chem 1998 : Small strains did not induce MMP-1 in VSMCs, but strain was a potent inhibitor of platelet derived growth factor ( PDGF ) - or tumor necrosis factor-alpha induced synthesis of MMP-1
Sato et al., Br J Dermatol 1998 : TNF-alpha increased the mRNA expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 both in monolayer and three-dimensional culture
Pender et al., J Immunol 1998 : Recombinant TNF-alpha and IL-1beta added directly to mucosal mesenchymal cell lines also caused an increase in MMP production, but only the former was inhibited by the TNFR-IgG
Uitto et al., Am J Pathol 1998 (Gingivitis...) : In these cells, MMP-13 expression at the mRNA and protein level was potently enhanced ( up to sixfold ) by tumor necrosis factor-alpha , transforming growth factor-beta(1), and transforming growth factor-alpha and by keratinocyte growth factor in the presence of heparin
Mentzel et al., Clin Exp Rheumatol 1998 (Arthritis, Reactive) : TNF-alpha increased the total MMP activity released
Singer et al., Eur J Biochem 1999 : Three categories of gene expression were identified : ( a ) MMP-13, -15 and -16 mRNAs were not detected despite stimulation by various cytokines ; ( b ) MMP-2 and -14 as well as TIMP-1, -2 and -3 mRNAs were constitutively expressed but not markedly affected by the six cytokines tested ; ( c ) mRNAs for MMP-1, -9 and -11 were selectively induced by specific cytokines : insulin-like growth factor-II, epidermal growth factor (EGF), platelet derived growth factor (PDGF)-BB and interleukin (IL)-6 stimulated MMP-11 expression ; MMP-1 was induced by EGF, PDGF-BB, tumour necrosis factor (TNF)alpha and IL-1alpha, which also exerted additive effects
Knittel et al., J Hepatol 1999 : In general, TNF-alpha stimulated both MMP and TIMP expression of hepatic stellate cells, while TGF-beta1 induced TIMP expression only
Wassenaar et al., Clin Exp Immunol 1999 : This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma