◀ Back to WNT1
DVL2 — WNT1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of DVL2-RHOA
→
WNT1
(increases)
Habas et al., Cell 2001
Evidence: Since Daam1 binds to Dvl and RhoA, we tested whether Daam1 forms a ternary complex with Dvl and RhoA. We immunoprecipitated the endogenous RhoA from 293T cells treated with or without Wnt-1 CM. Strikingly, we found that the endogenous Dvl protein is associated with RhoA only upon Wnt stimulation (Figure 2G).
-
Reactome Reaction:
DVL2
→
WNT1
(reaction)
Rothbächer et al., EMBO J 2000, Wong et al., Nat Struct Biol 2000*, Axelrod et al., Genes Dev 2001*, Tree et al., Cell 2002*, Wong et al., Mol Cell 2003, Tamai et al., Mol Cell 2004, He et al., Development 2004, González-Sancho et al., Mol Cell Biol 2004*, Park et al., Curr Biol 2005*, Zeng et al., Nature 2005, Witzel et al., J Cell Biol 2006*, Fujii et al., Cancer Res 2007, Lee et al., EMBO J 2007*, Zeng et al., Development 2008, MacDonald et al., J Biol Chem 2008, Gao et al., Cell Signal 2010*, Tauriello et al., Proc Natl Acad Sci U S A 2012, González-Sancho et al., J Biol Chem 2013*, Li et al., Development 2013*, Boutros et al., Cell 1998*, Axelrod et al., Genes Dev 1998*
-
Reactome Reaction:
DVL2
→
WNT1
(indirect_complex)
Rothbächer et al., EMBO J 2000, Wong et al., Nat Struct Biol 2000*, Axelrod et al., Genes Dev 2001*, Tree et al., Cell 2002*, Wong et al., Mol Cell 2003, Park et al., Curr Biol 2005*, Witzel et al., J Cell Biol 2006*, Fujii et al., Cancer Res 2007, Lee et al., EMBO J 2007*, Zeng et al., Development 2008, Tauriello et al., Proc Natl Acad Sci U S A 2012, Li et al., Development 2013*, Boutros et al., Cell 1998*, Axelrod et al., Genes Dev 1998*
-
Reactome Reaction:
DVL2
→
WNT1
(direct_complex)
Mao et al., Mol Cell 2001, Tamai et al., Mol Cell 2004, He et al., Development 2004, Davidson et al., Nature 2005, Zeng et al., Nature 2005, Bilic et al., Science 2007, MacDonald et al., J Biol Chem 2008
Text-mined interactions from Literome
Strovel et al., J Biol Chem 2000
:
PP2C exists in a complex with
Dvl , beta-catenin, and Axin, a negative
regulator of
Wnt signaling
Habas et al., Cell 2001
:
Wnt/Fz activation of Rho
requires the cytoplasmic protein
Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates
Wnt induced
Dvl-Rho complex formation
Shiomi et al., Curr Biol 2003
(Eye Abnormalities) :
In the canonical pathway,
Wnt receptors
activate Dishevelled ( Dvl ) , which then blocks the degradation of a key signal transducer, beta-catenin, leading to the nuclear accumulation of beta-catenin and induction of Wnt target genes through TCF/LEF family transcription factors
Habas et al., Genes Dev 2003
:
Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the
Wnt induced
Dvl-Rho complex
González-Sancho et al., Mol Cell Biol 2004
:
Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that
Dvl phosphorylation is not
sufficient to activate canonical
Wnt/beta-catenin signaling ... We conclude that
Wnt induced phosphorylation of
Dvl is independent of LRP5/6 receptors and that canonical Wnts can elicit both LRP dependent ( to beta-catenin ) and LRP independent ( to Dvl ) signals
Bryja et al., Proc Natl Acad Sci U S A 2007
:
Inhibition of
Wnt signaling by CK1 inhibitors
reduced the binding of beta-arrestin to
Dvl
Gan et al., J Cell Biol 2008
:
Disrupting the interaction of Dvl with either c-Jun or beta-catenin suppresses canonical
Wnt signaling stimulated transcription, and the reduction of
Dvl diminished beta-catenin-TCF-4 association on Wnt target gene promoters in vivo
Etheridge et al., PLoS Genet 2008
(Heart Defects, Congenital...) :
Interestingly, global canonical Wnt signaling appeared largely unaffected in the double Dvl mutants, suggesting that low
Dvl levels are
sufficient for functional canonical
Wnt signals
Gao et al., Cell Signal 2010
:
In addition,
Dvl plays important roles in
Wnt-GSK3beta-microtubule signaling, Wnt-calcium signaling, Wnt-RYK signaling, Wnt-atypical PKC signaling, etc
Gao et al., Nat Cell Biol 2010
(Colonic Neoplasms) :
Here we show that autophagy negatively
regulates Wnt signalling by promoting
Dishevelled ( Dvl ) degradation
Perez et al., J Cell Biol 2011
(Neointima) :
Interfering with the
Dvl dependent
Wnt-PCP activation in a murine stented aortic graft injury model promotes extensive neointima formation, as shown by optical coherence tomography and histopathology
Sharma et al., J Biol Chem 2012
(Lafora Disease...) :
Overexpression of malin enhances the degradation of
dishevelled2 and
inhibits Wnt signaling, which is evident from the down-regulation of ß-catenin target genes and the decrease in ß-catenin mediated transcriptional activity
Wei et al., Mol Cell Biol 2012
(Wnt Signaling Pathway) :
ITCH ubiquitinates the phosphorylated form of
Dvl and promotes its degradation via the proteasome pathway, thereby
inhibiting canonical
Wnt signaling ... Consistently, overexpression of ITCH
inhibited wild-type
Dvl2 induced, but not Dvl2-Y568F mutant induced,
Wnt reporter activity
Barry et al., Nature 2013
(Colorectal Neoplasms...) :
DVL signals in the nucleus of intestinal stem cells, and its forced expression
leads to enhanced
Wnt signalling in crypts
González-Sancho et al., J Biol Chem 2013
:
Functional Consequences of
Wnt induced
Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling
Ding et al., J Biol Chem 2013
(Wnt Signaling Pathway) :
Consistent with the
role of
Dvl in both
Wnt/ß-catenin and Wnt/planar cell polarity signaling, NEDD4L regulates the cellular ß-catenin level and Rac1, RhoA, and JNK activities
Goto et al., PloS one 2013
:
In Xenopus embryos, depletion of IQGAP1 reduced
Wnt induced nuclear accumulation of
DVL , and expression of Wnt target genes during early embryogenesis
Brigelius-Flohé et al., Methods Enzymol 2013
:
NOX1 derived H2O2 oxidizes Nrx leading to the liberation of
Dvl and the
activation of
Wnt signaling