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CISH — LEP
Text-mined interactions from Literome
Bjørbaek et al., J Biol Chem 1999
:
We here show that in CHO cells stably expressing the long form of the leptin receptor ( CHO-OBRl ),
leptin induces transient expression of endogenous SOCS-3 mRNA but not of
CIS , SOCS-1, or SOCS-2 mRNA
Harris et al., J Clin Invest 2001
:
As assessed by
leptin induced expression of
suppressor of cytokine signaling-3 ( SOCS-3 ) in fasted rats, TRH neurons in the paraventricular nucleus are activated directly by leptin
Hosoi et al., Brain Res 2002
:
Although
leptin did not
induce STAT3 activation or
suppressor of cytokine signaling3 ( SOCS3 ) expression in the hypothalamus of the db/db mice, which lack a functional Ob-Rb receptor, leptin increased the IL-1beta levels to similar extents as normal mice
Russo et al., Endocrinology 2004
(Neuroblastoma) :
In SH-SY5Y cells,
leptin induced signal transducer and activator of transcription ( STAT ) -3 phosphorylation and
suppressor of cytokine signaling-3 mRNA expression
Laubner et al., Diabetes 2005
(Insulinoma...) :
Leptin also
induced mRNA expression of the JAK-STAT inhibitor
suppressor of cytokine signaling (SOCS)3 in INS-1 beta-cells and human pancreatic islets in vitro and in pancreatic islets of ob/ob mice in vivo
Carlo et al., Endocrinology 2007
:
Furthermore,
leptin stimulation
increased the
suppressor of cytokine signaling-3 mRNA levels at P14, P21, and P28 in several hypothalamic nuclei but not at P7, indicating that selective leptin insensitivity in the hypothalamus is coupled to developmental shifts in leptin receptor signaling
Gong et al., Endocrinology 2008
(Body Weight...) :
Stat3 deletion in Agrp/Npy neurons also resulted in altered hypothalamic gene expression indicated by increased Npy mRNA and decreased induction of
suppressor of cytokine signaling-3 in
response to
leptin
Briancon et al., Diabetes 2010
(Insulin Resistance...) :
Suppressor of cytokine signaling (SOCS)-3 and protein-tyrosine phosphatase 1B (PTP-1B) are two endogenous inhibitors of tyrosine kinase signaling pathways and
suppress both insulin and
leptin signaling via different molecular mechanisms
Alcazar et al., Endocrinology 2012
(Inflammation...) :
In addition,
SOCS-3 is
induced by both
leptin and inflammatory cytokines