Allan et al., J Biol Chem 2001
:
Activating transcription factor 3 induces DNA synthesis and expression of cyclin D1 in hepatocytes ... Northern blot analysis and co-transfection experiments demonstrate that overexpression of ATF3 enhances cyclin D1 mRNA expression and activates the cyclin D1 promoter 2.5-fold when activating protein-1 (AP-1) and cyclic AMP response element ( CRE ) sites within the promoter are intact ... These results indicate that ATF3 expression stimulates hepatocellular proliferation, suggesting that this effect is mediated, at least in part, by the ATF3 dependent activation of cyclin D1 transcription
Recio et al., Oncogene 2002
(Melanoma) :
We here report that HGF/SF can induce cyclin D1 expression in mouse melanoma cells, and that this up-regulation is mediated in part by the activating transcription factor-2 ( ATF-2 )
James et al., BMC molecular biology 2006
:
Our data suggest that transcriptional induction of the Atf3 gene in maturing chondrocytes results in down-regulation of cyclin D1 and cyclin A expression as well as activation of RUNX2 dependent transcription
Wang et al., International journal of molecular sciences 2013
:
Overexpression of ATF3 increased CCND1/2 expression in PC3 and DU145 cancer cells ... Interestingly, we observed that SUMOylation is essential for ATF3 mediated CCND1/2 activation