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CCND1 — E2F3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Vandel et al., Mol Cell Biol 2001
Evidence: assay
-
Reactome Reaction:
CCND1
→
E2F3
(reaction)
Connell-Crowley et al., Mol Biol Cell 1997
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
E2F3
—
CCND1
(interaction, mapped from grid bind)
-
STRING interaction:
CCND1
—
E2F3
(interaction, mapped from grid bind)
Text-mined interactions from Literome
Lee et al., Mol Cell Biol 2000
(Cell Transformation, Neoplastic...) :
NeuT induction of the
cyclin D1 promoter
required the
E2F and Sp1 DNA binding sites and was inhibited by dominant negative E2F-1 or DP-1
Beier et al., Mol Biol Cell 2001
:
Inhibition of
cyclin D1 expression with antisense oligonucleotides causes a delay in progression of chondrocytes through the G1 phase of the cell cycle,
reduced E2F activity, and decreased proliferation
Dai et al., Cell cycle (Georgetown, Tex.) 2006
(Multiple Myeloma) :
In pRb-null U266 cells, enforced overexpression of
cyclin D1 diminished CDK inhibitor mediated dephosphorylation of the pocket proteins p130 and p107, reduced binding of E2F1 and E2F4 to p130 and p107, and
attenuated inhibition of
E2F activity
Schulze et al., Oncogene 1994
:
Activation of the
E2F transcription factor by
cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1 ... The data reported here support a direct
role for
cyclin D1 and its associated kinase in cell cycle regulation of
E2F activity and S phase-specific gene expression
Watanabe et al., Mol Cell Biol 1998
:
Inhibition of cyclin D1 kinase activity is associated with
E2F mediated inhibition of
cyclin D1 promoter activity through E2F and Sp1 ... In contrast with E2F-1,
E2F-4 induced
cyclin D1 promoter activity