◀ Back to HDAC3
HDAC3 — RELA
Pathways - manually collected, often from reviews:
-
BioCarta acetylation and deacetylation of rela in nucleus:
HDAC3
→
NF-kappa-B complex (RELA)
(modification, activates)
-
BioCarta acetylation and deacetylation of rela in nucleus:
HDAC3
→
p300/CBP/RELA/p50 complex (EP300-CREBBP-RELA)
(modification, activates)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
I kappa B alpha/HDAC3 complex (NFKBIA-HDAC3)
→
NF kappa B/RelA complex (RELA)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
I kappa B alpha/HDAC3 complex (NFKBIA-HDAC3)
→
NF kappa B/RelA/I kappa B alpha complex (NFKBIA-RELA)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NF kappa B/RelA complex (RELA)
→
HDAC3 (HDAC3)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NF kappa B/RelA/I kappa B alpha complex (NFKBIA-RELA)
→
HDAC3 (HDAC3)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
I kappa B alpha/HDAC3 complex (NFKBIA-HDAC3)
→
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
I kappa B alpha/HDAC3 complex (NFKBIA-HDAC3)
→
NF kappa B1 p50/RelA complex (NFKB1-RELA)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NF kappa B1 p50/RelA/I kappa B alpha complex (NFKB1-NFKBIA-RELA)
→
HDAC3 (HDAC3)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC3 (HDAC3)
→
NF kappa B1 p50/RelA complex (NFKB1-RELA)
(modification, collaborate)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC3
—
RELA
(physical association, affinity chromatography technology)
Chen Lf et al., Science 2001*
-
IRef Biogrid Interaction:
HDAC3
—
RELA
(physical association, affinity chromatography technology)
Hu et al., Carcinogenesis 2004*
-
IRef Hprd Interaction:
RELA
—
HDAC3
(in vitro)
Chen Lf et al., Science 2001*, Kiernan et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
RELA
—
HDAC3
(in vivo)
Chen Lf et al., Science 2001*, Kiernan et al., J Biol Chem 2003*
-
IRef Intact Interaction:
HDAC3
—
RELA
(physical association, coimmunoprecipitation)
Chen Lf et al., Science 2001*
Text-mined interactions from Literome
Foss et al., Leukemia & lymphoma 2003
(Lymphoma, T-Cell, Cutaneous) :
Other novel agents include the interleukin (IL)-2 fusion toxin ( ONTAK ), pentostatin ( a potent adenosine deaminase inhibitor ),
histone deacetylase inhibitors such as depsipeptide,
NF-kappaB inhibitors , cytokine receptor antagonists, immunomodulatory therapies and allogeneic stem cell therapy
Glauben et al., Gut 2008
(Colitis...) :
As for potential mechanisms of ITF2357 action, increased acetylation of histone 3, reduced production of IFN gamma and enhanced apoptosis in lamina propria mononuclear cells were found to accompany a
histone deacetylase dependent
activation of
NF-kappaB
Hayes et al., Eur J Nutr 2008
(Neoplasms) :
In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 ( NF-E2 related factor 2 ) and AhR ( arylhydrocarbon receptor ) transcription factors, and their abilities to repress
NF-kappaB ( nuclear factor-kappaB ) activity,
inhibit histone deacetylase , and inhibit cytochrome P450 are outlined