◀ Back to BMP2

ACAN — BMP2

Text-mined interactions from Literome

Seghatoleslami et al., J Cell Biochem 2003 : While high expression of aggrecan and type IIB collagen genes were dependent on BMP-2 signaling, ERK inhibition of BMP-2 treated micromass cultures resulted in reduced activity of both genes
Li et al., J Orthop Sci 2003 : Both BMP-2 and CDMP-2 significantly enhanced proteoglycan production and aggrecan mRNA expression in a dose dependent manner, although BMP-2 is more effective than CDMP-2 in increasing sulfated proteoglycan production
Kim et al., Spine (Phila Pa 1976) 2003 : To demonstrate the effect of BMP-2 on mRNAs expression ( collagen type I, collagen type II, aggrecan , and osteocalcin ), proteoglycan synthesis, expression of alkaline phosphatase, bone nodule formation in human IVD cells
Gründer et al., Osteoarthritis Cartilage 2004 : Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads
Li et al., J Spinal Disord Tech 2004 : BMP-2 significantly increased aggrecan and collagen type II mRNA expression 8.30 and 4.61 times, respectively, and decreased versican mRNA expression 0.54 times as compared with control ... The results of this study show that in rat intervertebral disc cells, BMP-2 increases aggrecan and collagen type II mRNA expression and decreases versican gene expression
Estes et al., Arthritis Rheum 2006 : Most notably, BMP-6 up-regulated AGC1 and COL2A1 expression by an average of 205-fold and 38-fold, respectively, over day-0 controls, while down regulating COL10A1 expression by approximately 2-fold
Lincoln et al., Dev Biol 2006 : In multiple assays of cells from prefused endocardial cushions, BMP2 is sufficient to activate Smad1/5/8 phosphorylation and induce sox9 and aggrecan expression, while FGF4 treatment increases phosphorylated MAPK ( dpERK ) signaling and promotes expression of scleraxis and tenascin
Blaney Davidson et al., Arthritis Res Ther 2007 : BMP-2 overexpression also induced increased aggrecan degradation in cartilage
Ando et al., Acta Orthop 2009 : The presence of BMP-2 and bFGF clearly enhanced the aggrecan and type II collagen expression of 3D-embedded chondrocytes
Smith et al., J Orthop Res 2011 (Osteoarthritis, Knee) : Articular chondrocytes, isolated from femoral OA cartilage and maintained in high-density monolayer culture, were examined for effects of BMP-2 and IHP on gene expression of matrix associated proteins ( aggrecan , type II collagen, and SOX9 ) and catabolic matrix metalloproteinases ( MMP-2 and MMP-3 ) and culture medium levels of the metabolic markers MMP-2, nitric oxide ( NO ), and glycosaminoglycan ( GAG ) ... Type II collagen and SOX9 gene expression were stimulated by both IHP and BMP-2 whereas aggrecan was increased only by BMP-2
Haschtmann et al., Eur Spine J 2012 (Intervertebral Disc Degeneration) : In the annulus fibrosus ( AF ), TGF-ß3 and BMP-2 resulted in an up-regulation of Col I and type II, and of aggrecan gene expression
Rui et al., J Orthop Res 2013 (Tendinopathy) : BMP-2 promoted the osteogenic, adipogenic, and chondrogenic differentiation but inhibited tenogenic marker expression of TDSCs. GAG production and Acan increased while Dcn, Bgn, and Fmod decreased in TDSCs after BMP-2 stimulation ... In conclusion, BMP-2 promoted GAG deposition, aggrecan expression, and enhanced non-tenocyte differentiation of TDSCs in vitro