Gene interactions and pathways from curated databases and text-mining

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CRK — RAC3

Text-mined interactions from Literome

Abassi et al., EMBO J 2002 (MAP Kinase Signaling System) : Tyrosine 221 in Crk regulates adhesion dependent membrane localization of Crk and Rac and activation of Rac signaling
Yeo et al., Cell Adh Migr 2008 : v-Crk regulates membrane dynamics and Rac activation
Zhang et al., J Biol Chem 2009 (Breast Neoplasms...) : Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac dependent p38 and JNK signaling
Zhang et al., J Biol Chem 1995 : A dominant negative Pak1 suppresses both interleukin-1- and Rac/Cdc42 induced p38 activity
Altun-Gultekin et al., Mol Cell Biol 1998 : Expression of v-Crk in PC12 cells does not result in activation of Rac- or Cdc42 dependent kinases PAK and S6 kinase, demonstrating specificity for Rho
Dolfi et al., Proc Natl Acad Sci U S A 1998 : JNK activation by Cas and Crk was effectively blocked by a dominant negative form of Rac , suggesting for a linear pathway from the Cas-Crk-complex to the Rac-JNK activation