Maile et al., J Biol Chem 2002
:
These studies indicate that IGF-IR stimulates phosphorylation of SHPS-1 which is critical for SHP-2 recruitment to the plasma membrane and for its recruitment to the IGF-IR
Shen et al., Cell Mol Life Sci 2010
(MAP Kinase Signaling System) :
In vascular smooth muscle cells, IGF-I stimulates SHPS-1/SHP2/Src complex formation which is required for IGF-I stimulated cell proliferation