Shu et al., PloS one 2011
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Pretreatment with AGEs receptor ( RAGE ) antibody also prevented the AGE induced diminution of Pdx-1 protein and insulin mRNA expression
Sano et al., J Biol Chem 1998
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Insulin caused a 1.7-fold increase in the endocytic degradation of 125I-AGE-BSA by these cells, the effect of which was also inhibited by wortmannin and LY294002, another PI3 kinase inhibitor