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AHSA1 — RELA

Text-mined interactions from Literome

Norris et al., J Biol Chem 1999 : These experiments show that Ras utilizes Raf dependent and Raf independent pathways to activate NF-kappaB transcriptional activity, both of which require the stress activated kinase p38 or a related kinase
Eliopoulos et al., J Biol Chem 1999 : We have found that inhibition of p38 by the highly specific inhibitor SB203580 did not affect NF-kappaB binding activity
Liang et al., J Clin Invest 1999 (Cardiomegaly) : Thus, induction of the hBNP promoter by mechanical strain depends, at least in part, on stimulation of p38 and subsequent activation of NF-kappaB
Ivanov et al., Oncogene 2000 (Melanoma) : Inhibition of p38 activity also restored NF-kappaB activity and Fas expression in early-phase melanoma cells, suggesting that p38 elicited suppression of Fas expression is not restricted to late phase melanoma
Arcaroli et al., Clin Immunol 2001 (Endotoxemia...) : Similarly, the increased production of proinflammatory cytokines and activation of NF-kappaB in lung neutrophils induced by hemorrhage or endotoxemia was not diminished by p38 inhibition
Mendes et al., Nitric Oxide 2002 : The p38MAPK inhibitor, SB 203580, had no effect on IL-1 induced NF-kappaB activation
Korus et al., Oncogene 2002 (MAP Kinase Signaling System) : p38 MAPK mediated activation of NF-kappaB by the RhoGEF domain of Bcr
Bian et al., Exp Eye Res 2003 (Translocation, Genetic) : These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB , PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells
Park et al., Oncogene 2003 (Prostatic Neoplasms) : IL-6 activation by TGF-beta1 was accompanied by nuclear translocation of NF-kappaB , which was blocked by the p38 inhibitors SB202190 and SB203580 or by IkappaBalphaDeltaN transfection, indicating the crucial role for the p38-NF-kappaB signaling in TGF-beta1 induction of IL-6
Kang et al., Toxicol Appl Pharmacol 2003 : These data suggest that FeTMPyP downregulates the proliferative activity by inhibition of p38 MAPK activation, NF-kappaB activation , and IL-2 secretion during mitogenic stimulation of thymocytes
Kato et al., J Am Soc Nephrol 2004 (Peritonitis) : mRNA expression of MCP-1 was abolished by NF-kappaB inhibition, but were not affected by the inhibition of ERK, JNK, or p38
Weldon et al., Int J Oncol 2004 (Breast Neoplasms) : The effect of p38 inhibition on NF-kappaB transcriptional activation was analyzed
Kuphal et al., Oncogene 2004 (Melanoma) : In summary, we conclude that loss of E-cadherin and cytoplasmatic beta-catenin induces p38 mediated NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas
Shim et al., J Biol Chem 2005 (Inflammation...) : Pretreatment with protein kinase C ( PKC ) inhibitor blocked the TPA induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38 , JNK, MEK activity had no effect on TPA induced NAG-1 levels and NF-kappa B transcriptional activity
Costantini et al., J Mol Neurosci 2005 (Neuroblastoma) : Finally, we demonstrated that NF-kappaB activation is dependent on p38 and JNK activation
Chandrasekar et al., Biochem Biophys Res Commun 2006 : IL-18 induced activation of NF-kappaB and PTEN upregulation were mediated by p38MAPK
Syeda et al., J Biol Chem 2006 : Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK
Rydkina et al., Ann N Y Acad Sci 2005 : Our data also suggest that p38 activity does not contribute to NF-kappaB response, implicating involvement of independent upstream signaling pathways
Sunahori et al., Arthritis Res Ther 2006 (Arthritis, Rheumatoid) : NF-kappaB activation was induced in S100A8/A9 stimulated monocytes, but this activity was not inhibited by p38 MAPK inhibitors
Li et al., Cancer Res 2006 (Multiple Myeloma) : The secretion of IL-6 by BMSCs was completely inhibited by 10 ( -9 ) mol/L PACAP, which also attenuated the phosphorylation of both p42/44 and p38 mitogen activated protein kinases ( MAPK ) as well as nuclear factor-kappaB (NF-kappaB) activation in response to the adhesion of multiple myeloma cells to BMSCs, whereas the inhibition of p42/44 MAPK signaling attenuated PACAP action
Das et al., Free radical research 2006 (Myocardial Infarction...) : Cardioprotective effect of resveratrol via HO-1 expression involves p38 map kinase and PI-3-kinase signaling, but does not involve NFkappaB
Olson et al., Infect Immun 2007 : We now show that p38 MAP kinase activity regulates the transcriptional activation of NF-kappaB in response to spirochetal lysate stimulation of phagocytic cells
Thoms et al., Cancer Res 2007 (Colorectal Neoplasms...) : Indeed, chemical p38 inhibition ( PD169316 ) and small interfering RNA directed against p38 blocked aspirin induced cyclin D1 degradation, nucleolar translocation of RelA , and apoptosis
Ryan et al., Biochem Biophys Res Commun 2007 (Anoxia) : Furthermore, depletion of p38 using siRNA significantly reduces IHR induced NF-kappaB activity
Peng et al., Toxicology 2007 (Glioma) : Inhibition of ERK, p38 and JNK block the activation of AP-1 and NF-kappaB , suggesting these MAPKs are involved in ( Ac ) ( 5 ) GP-induced transcription regulation
Kim et al., Chem Biol Interact 2008 : These results suggest that both p38 and ERK MAPKs activates NF-kappaB signaling, which in turn induces COX-2 expression in TPA stimulated human mammary epithelial cells
Saha et al., J Immunol 2007 (Inflammation) : MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65 ... However, the molecular mechanism of p38 mediated regulation of NF-kappaB remains largely unknown
Yang et al., Molecular vision 2007 (Radiation Injuries) : These results also suggest that p38 , p44/42, and JNK may regulate glial induced photoreceptor death and that p38, JNK, and NF-kappaB may regulate photoreceptor induced microglial activation
Stuhlmeier et al., Exp Gerontol 2009 (Arthritis) : Data are presented that show that the effects of HT on p38 are clearly independent of HT effects on NF-kappaB
Li et al., Am J Physiol Cell Physiol 2009 : Both IL-1 isoforms stimulate phosphorylation of p38 mitogen activated protein kinase and stimulate nuclear factor-kappaB (NF-kappaB) signaling ; I-kappaB levels fall and NF-kappaB DNA binding activity increases
Yu et al., J Biol Chem 2009 (Inflammation...) : In addition, IDR-1 induced p38 MAPK activity in a p62 dependent manner and increased CCAAT-enhancer binding protein beta activity, whereas NF-kappaB activity was unaffected
Santos et al., Expert Opin Ther Targets 2010 (Inflammation...) : It suppresses p38 ( implicated in glucocorticoid-resistance ) and inhibits NF-kappaB activation, which has an important pathogenic role in several lung diseases
Zhao et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy...) : Furthermore, the activation of NF-kappaB was significantly affected by ERK1/2 and JNK inhibitors, but not by p38
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In THP-1 cells, p38 , ERK, and JNK inhibition increased NF-kappaB and Sp1 binding to the IL-12p40 promoter, while inhibiting AP-1 binding
Zawawi et al., J Periodontal Res 2010 : Blockage of moesin function interrupts the LPS response through an inhibition of MyD88, IRAK and TRAF6, negatively affecting subsequent activation of the MAP kinases ( p38 and ERK ), NF-kappaB activation and translocation to the nucleus