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RIPK2 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RIPK2 → TNF (increases, TNF Activity)
  Evidence: RIP2 is a serine-threonine kinase associated with the tumor necrosis factor (TNF) receptor complex and is implicated in the activation of NF-kappaB and cell death in mammalian cells.

Text-mined interactions from Literome

Windheim et al., Biochem J 2007 : Thus pharmacological inhibition of RIP2 kinase with either SB 203580 [ a p38 MAPK ( mitogen activated protein kinase ) inhibitor ] or the Src family kinase inhibitor PP2 induces a rapid and drastic decrease in the level of the RIP2 protein, which may explain why these RIP2 inhibitors block MDP stimulated downstream signalling and the production of IL-1beta ( interleukin-1beta ) and TNFalpha ( tumour necrosis factor-alpha )
Liu et al., Zhonghua Nei Ke Za Zhi 2007 : Blocking of Rip2 could attenuate LPS induced TNFalpha and HMGB1 production
Farkas et al., Scand J Immunol 2008 : Our study provides evidence that NOD2, toll-like receptor 4 (TLR4) and the adapter protein receptor interacting protein 2 (RIP2) are induced by tumor-necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in the bronchial epithelial cell line BEAS-2B