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HSD11B1 — IGF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HSD11B1 → IGF1 (decreases, IGF1 Activity)
  Evidence: in an in vitro model, IGF1 at physiological doses inhibits HSD11B1 in omental pre-adipocytes and stably transfected cell lines, thereby decreasing local cortisol generation
• OpenBEL Selventa BEL large corpus: HSD11B1 → IGF1 (decreases, IGF1 Activity) Whorwood et al., J Clin Endocrinol Metab 2001*
  Evidence: Incubation with insulin-like growth factor I resulted in a similar pattern of 11betaHSD1 activity.
• OpenBEL Selventa BEL large corpus: HSD11B1 → IGF1 (increases, IGF1 Activity) Whorwood et al., J Clin Endocrinol Metab 2001*
  Evidence: Incubation with insulin-like growth factor I resulted in a similar pattern of 11betaHSD1 activity.

Text-mined interactions from Literome

Whorwood et al., J Clin Endocrinol Metab 2001 (Insulin Resistance) : Additionally, insulin and insulin-like growth factor I regulation of 11betaHSD1 may represent a novel mechanism that maintains insulin sensitivity in skeletal muscle tissue by diminishing glucocorticoid antagonism of insulin action
Morita et al., Endocr J 2009 : In conclusion, 11beta-HSD1 activity was suppressed by GH or IGF-I in differentiated adipocytes, probably due to a reduction of 11beta-HSD1 mRNA levels
Huang et al., Biochem Biophys Res Commun 2010 : Regulation of 11beta-hydroxysteroid dehydrogenase 1 and 2 by IGF-1 in mice