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DISC2 — FAS

Text-mined interactions from Literome

Algeciras-Schimnich et al., Mol Cell Biol 2002 : Binding of either ligand or agonistic antibodies to the death receptor CD95 ( APO-1/Fas ) induces the formation of the death inducing signaling complex ( DISC )
Mori et al., Int J Oncol 2002 (Acquired Immunodeficiency Syndrome...) : Fas engagement rapidly induces formation of the death inducing signaling complex ( DISC ) that consists of Fas, FADD and pro-caspase-8
Lajmanovich et al., Br J Haematol 2004 (Lymphoma, B-Cell) : Finally, we report the absence of a CD95 induced signalling complex [ death inducing signalling complex ( DISC ) ] in lymphoma B cells, with no FADD and caspase-8 recruitment to CD95 receptor
Eberle et al., Hepatology 2005 : The requirement of EGFR mediated CD95 tyrosine phosphorylation for hyperosmotic and CD95L induced CD95 membrane targeting and DISC formation was also shown in CD95 mutagenesis experiments
Chen et al., J Cell Biochem 2008 (Bile Duct Neoplasms...) : Characterization of the role of CaM in Fas mediated DISC formation and apoptosis signaling may provide important insights in the development of novel therapeutic targets for cholangiocarcinoma
Yang et al., Clin Exp Pharmacol Physiol 2007 (Glioma...) : 2. Twelve tumour cell lines were examined for their sensitivity to CH-11 induced apoptosis and then two of each of the CH-11-sensitive and -resistant tumour cell lines were analysed for Fas mediated death inducing signalling complex ( DISC )
Yang et al., Blood 2008 (Leukemia, Large Granular Lymphocytic) : Our results demonstrate that expanded T cells in patients with LGL leukemia display both functional and phenotypic characteristics of prior antigen activation in vivo and display reduced capacity for Fas mediated DISC formation
Buron et al., Invest Ophthalmol Vis Sci 2008 : First, TFF1 prevents caspase-8 activation at the level of the DISC that involves Fas receptor in plasma membrane rafts, which in turn decreases the mitochondrial release of cytochrome c
Suever et al., Biophys J 2008 : However, the molecular mechanisms whereby Fas mutations and CaM/Fas binding might regulate Fas mediated DISC formation are unknown ... The results presented here provide structural evidence for the roles of Fas mutations and CaM/Fas binding in Fas induced DISC formation ... Understanding the molecular mechanisms of CaM/Fas binding in Fas mediated DISC formation should provide important insights into the function of Fas mutations and CaM in regulating Fas mediated apoptosis
Fuchs et al., Pediatr Res 2009 (Autoimmune Diseases...) : Sensitivity to CD95 induced cell-death, assembly of the CD95-death inducing signaling complex ( DISC ), and activity of initiator caspases-8 and -10 were compared in EBV transformed B-lymphoblastoid cells of these patients ... All CD95-mutations led to a reduced DISC formation and diminished initiator caspase activity upon CD95-stimulation, whereas a marked heterogeneity in sensitivity to CD95 induced killing was found
Pan et al., Proteins 2011 : Previous experiments have demonstrated that the calmodulin (CaM) antagonist, trifluoperazine (TFP) regulates CaM-Fas binding and affects Fas mediated DISC formation ... The computational results from this study reveal the structural and molecular mechanisms that underlie the role of the CaM antagonist, TFP, in regulation of CaM-Fas binding and Fas mediated DISC formation in a concentration dependent manner
Kober et al., Cell death & disease 2011 (MAP Kinase Signaling System) : We found that CD95 DISC induced caspase-8 activity is important for the initiation of ERK1/2 and p38 MAPK activation