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FOS — MYC
Pathways - manually collected, often from reviews:
-
BioCarta il-2 receptor beta chain in t cell activation:
c-MYC (MYC)
→
c-FOS (FOS)
(cell proliferation, activates)
-
FastForward regulation:
FOS, JUN
→
MYC
(transcriptional regulation, unknown)
Hiebert et al., Proc Natl Acad Sci U S A 1989
Evidence: DNABINDING, PROMACTIVITY, REG
-
FastForward regulation:
FOS, JUN
→
MYC
(transcriptional regulation, unknown)
Mudryj et al., EMBO J 1990*
Evidence: DNABINDING, PROMACTIVITY, REG
Text-mined interactions from Literome
Kalra et al., J Biol Chem 2004
(Carcinoma, Hepatocellular...) :
Deletion analysis of the promoter region of the c-fos gene indicated that the ATF2-responsive element conferred the
Myc induced expression of
c-Fos
Asim et al., J Biol Chem 2010
(Helicobacter Infections) :
A dominant negative
c-Fos inhibited H. pylori
induced expression of
c-Myc and ODC and apoptosis
Enan et al., Biochem Pharmacol 1995
:
Under in situ incubation conditions with explant tissues in culture, TCDD rapidly
enhanced the DNA binding activity of the transcriptional factor
AP-1 , whereas the same treatment reduced
c-Myc DNA binding activity ... On the other hand, in the presence of forskolin, the stimulatory effect of TCDD on
AP-1 binding activity and the inhibitory
effect on
c-Myc were still apparent
Wu et al., Oncogene 1993
(Carcinoma...) :
Western blot analysis also showed that
c-Fos was
induced at 4-6 h and at 1-4 h after treatment with 50 microM and 200 microM VK3 respectively, while
c-Myc was induced at 1-6 h and at 4-6 h, respectively, after such treatments