Gao et al., J Immunol 2007
:
Osteopontin induces ubiquitin dependent degradation of STAT1 in RAW264.7 murine macrophages
Gao et al., Neoplasia (New York, N.Y.) 2007
(Mammary Neoplasms, Experimental...) :
Osteopontin regulates ubiquitin dependent degradation of Stat1 in murine mammary epithelial tumor cells ... Our results demonstrate that OPN regulates Stat1 protein degradation through the ubiquitin-proteasome pathway to alter interferon-gamma dependent growth inhibition and p21 expression
Guo et al., Surgery 2008
(Sepsis) :
Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis ... Exogenous OPN or MG132 restored Ub-P-Stat1 and iNOS to levels seen in WT
Guo et al., J Biol Chem 2010
:
In this regard, using a murine macrophage model of LPS stimulation, we previously demonstrated that osteopontin (OPN) increased STAT1 ubiquitination and 26 S proteasome degradation via the ubiquitin E3 ligase, PDLIM2