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MAPK6 — SYT1

Text-mined interactions from Literome

Ha et al., Proc Natl Acad Sci U S A 2004 : Here, we demonstrate an additional mechanism whereby a significant reduction of proinflammatory gene expression such as IL-1beta, tumor necrosis factor alpha, and inducible nitricoxide synthase in PARP-1 ( -/- ) glial cells is linked to defective inflammatory stimuli induced p38MAPK mediated phosphorylation of ATF-2 and cAMP-response element binding protein and phosphorylation of NF-kappaB p65
Syeda et al., J Biol Chem 2006 : Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK
Calleros et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here, we found that inhibition of p38 MAPK with the specific inhibitor SB203580 blocked the increase in NFkappaB activity, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion
Khan et al., Photochem Photobiol 2012 (Hyperplasia) : Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB induced ( 1 ) nuclear translocation and phosphorylation of nuclear factor kappa B/p65 , ( 2 ) phosphorylation and degradation of I?Ba, ( 3 ) activation of IKKa/???ß and ( 4 ) phosphorylation of mitogen activated protein kinase proteins and c-Jun
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )