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FAS — NOS2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FAS → NOS2 (increases, FAS Activity) Garbán et al., Gynecol Oncol 1999*
  Evidence: These findings demonstrate that sensitization of human ovarian carcinoma cell lines to Fas-mediated apoptosis by IFN-gamma can be due, in part, to the induction of iNOS and the subsequent upregulation of Fas gene expression by reactive nitrogen intermediates

Text-mined interactions from Literome

Chun et al., Toxicol Lett 2003 (Adenocarcinoma...) : Fas receptor activation also increased the generation of reactive oxygen species, and N-acetylcysteine, a well-known antioxidant, could block Fas mediated iNOS induction ... Overall, iNOS induction and P450 3A4 suppression by Fas activation may cause toxic cellular damage in gastrointestinal tissues
Takemura et al., Hypertension 2004 : Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression ... Here, we report that Fas engagement with Fas ligand induced activation of Akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis
Bai-Feng et al., Diabetes Res Clin Pract 2010 : Silencing iNOS by RNAi prevented the up-regulation of Bax and Fas induced by cytokine, thus reduced apoptosis of islets and recovered the insulin secretion index ( 3.43+/-0.24 vs 1.87+/-0.31, P < 0.01 )