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BMP4 — LEF1

Text-mined interactions from Literome

Choe et al., J Neurosci 2013 : We tested the hypothesis that Bmp signaling regulates dentate development in part by controlling the expression of Lef1 , a Wnt responsive transcription factor expressed in dentate stem cells and absolutely required for dentate granule cell production ... Bmp activation through the Acvr1 receptor induced Lef1 expression and neurogenesis in the embryonic DG ... These results suggest that Acvr1 mediated meningeal Bmp signaling regulates Lef1 expression in the dentate, regulating embryonic DG neurogenesis, DG neural stem cell niche formation, and maintenance
Kratochwil et al., Genes Dev 1996 : Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development ... In addition, the finding that the expression of Lef1 can be activated by bone morphogenetic protein 4 (BMP-4) suggests a regulatory role of this transcription factor in BMP mediated inductive tissue interactions
Chen et al., Development 1996 : BMP4 soaked beads can induce Bmp4 and Lef1 expression in explanted wild-type dental mesenchymes, but only Lef1 expression in Msx1 mutant dental mesenchyme
Dassule et al., Dev Biol 1998 : For example, epithelially expressed Bmp4 induces Msx1 and Lef1 as well as itself in the underlying mesenchyme ... Interestingly, both Bmp and Wnt signaling activate Lef1 , making it a candidate for integrating the two distinct signaling pathways