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NFKB1 — NLRP12
Text-mined interactions from Literome
Williams et al., J Biol Chem 2005
(Inflammation) :
Monarch-1 reduces
NFkappaB activation by TLR signaling molecules MyD88, IRAK-1 ( type I interleukin-1 receptor associated protein kinase ), and TRAF6 ( TNF receptor (TNFR) associated factor ) as well as TNFR signaling molecules TRAF2 and RIP1 but not the downstream NFkappaB subunit p65 ... Reducing
Monarch-1 expression with small interference RNA in myeloid/monocytic cells
caused a dramatic increase in
NFkappaB activation and cytokine expression in response to TLR2/TLR4 agonists, TNFalpha, or M. tuberculosis infection, suggesting that Monarch-1 is a negative regulator of inflammation
Lich et al., J Immunol 2007
(Inflammation) :
In this report, we show that
Monarch-1 inhibits CD40 mediated activation of
NF-kappaB via the non-canonical pathway in human monocytes ... This inhibition stems from the ability of
Monarch-1 to associate with and
induce proteasome mediated degradation of
NF-kappaB inducing kinase
Fontalba et al., J Immunol 2007
:
Thus,
NLRP2 may
control NF-kappaB activation through a regulatory loop