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BMP2 — TNF

Text-mined interactions from Literome

Fukui et al., J Bone Joint Surg Am 2003 (Osteoarthritis) : In cartilage explant cultures, IL-1beta and TNF-alpha increased BMP-2 levels both intracellularly and extracellularly
Cola et al., Biochem Biophys Res Commun 2004 (Calcinosis) : The effects of ox-LDL, but not TNFalpha , on MGP and BMP2 expression were inhibited by pretreatment of cells with an antibody directed at LOX-1, a lectin-like receptor for ox-LDL ( 10 microg/mL )
Shi et al., Inflamm Res 2004 (Chondrosarcoma...) : IL-1, but not TNF-alpha , can induce IL-6, bone morphogenic protein 2 (BMP-2) , and cyclooxygenase ( COX-2 ) expression in SW1353 cells
Kaneki et al., J Biol Chem 2006 : TNF inhibited the expression of bone morphogenetic protein and transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
He et al., Zhonghua Wai Ke Za Zhi 2006 : To study the feasibility of osteogenic phenotype expression by human skin fibroblasts induced in polyglycolic acid ( PGA ) foams and the effect of tumor necrosis factor-alpha (TNF-alpha) on the expression of bone morphogenetic protein ( BMP ) receptors
Singhatanadgit et al., Int J Biochem Cell Biol 2006 : Bone morphogenetic protein receptors and bone morphogenetic protein signaling are controlled by tumor necrosis factor-alpha in human bone cells
Fukui et al., J Biol Chem 2006 (Inflammation) : Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation ... In articular chondrocytes, the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) induces the expression of bone morphogenetic protein-2 (BMP-2) , a growth factor known to be involved in the induction of cartilage and bone ... In ATDC5 cells, the endogenous BMP-2 expression was consistently low throughout the process of chondrogenic differentiation, and TNF-alpha induced BMP-2 expression only after the cells acquired the chondrogenic phenotype
Li et al., J Bone Miner Res 2007 (Osteoporosis) : In vitro, TNFalpha suppresses BMP-2- and TGFbeta mediated Smad activation through induction of NF-kappaB
Hong et al., Immunology 2009 : In addition, BMP-6 induced expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine tumour necrosis factor (TNF)-alpha
Yamazaki et al., J Biol Chem 2009 : In this study, we found that TNFalpha inhibited the alkaline phosphatase activity and markedly reduced BMP2- and Smad induced reporter activity in MC3T3-E1 cells ... These results suggest that TNFalpha inhibits BMP signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB
Yao et al., Connect Tissue Res 2010 : TNF-alpha upregulates expression of BMP-2 and BMP-3 genes in the rat dental follicle -- implications for tooth eruption ... We found that BMP-3 expression is correlated with the expression of TNF-alpha in the dental follicle and TNF-alpha significantly increased BMP-2 and BMP-3 expression in vitro
Yan et al., Am J Pathol 2010 (Cicatrix...) : Indeed, TNF-alpha could induce BMP-2 and its receptor ( BMPR1A ) in human skin and primary keratinocytes, and BMP2 could induce EMT features in skin explants and primary keratinocytes
Pacios et al., FASEB J 2012 (Diabetes Mellitus, Experimental...) : TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone lining cells, and increased mRNA levels of FGF-2, TGFß-1, BMP-2 , and BMP-6
Nakase et al., Bone 1997 : The modulatory effects of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha on bone morphogenetic protein (BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells