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BMP5 — TNF

Text-mined interactions from Literome

Kaneki et al., J Biol Chem 2006 : TNF inhibited the expression of bone morphogenetic protein and transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
He et al., Zhonghua Wai Ke Za Zhi 2006 : To study the feasibility of osteogenic phenotype expression by human skin fibroblasts induced in polyglycolic acid ( PGA ) foams and the effect of tumor necrosis factor-alpha (TNF-alpha) on the expression of bone morphogenetic protein ( BMP ) receptors
Singhatanadgit et al., Int J Biochem Cell Biol 2006 : Bone morphogenetic protein receptors and bone morphogenetic protein signaling are controlled by tumor necrosis factor-alpha in human bone cells
Hong et al., Immunology 2009 : In addition, BMP-6 induced expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine tumour necrosis factor (TNF)-alpha
Yamazaki et al., J Biol Chem 2009 : These results suggest that TNFalpha inhibits BMP signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB
Pacios et al., FASEB J 2012 (Diabetes Mellitus, Experimental...) : TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone lining cells, and increased mRNA levels of FGF-2, TGFß-1, BMP-2 , and BMP-6