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HMOX1 — IL6

Text-mined interactions from Literome

Deramaudt et al., Proc Soc Exp Biol Med 1999 : This suggests that IL-6 induction of human HO-1 is mediated via the JAK-STAT pathway and that Dex inhibition of gene expression is carried out by activation of a transcriptional protein in competition with the STAT3 binding site
Tron et al., J Hepatol 2006 : Regulation of rat heme oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes ... Therefore, the aim of this study was to elucidate the molecular mechanisms responsible for IL-6 dependent HO-1 induction in the liver ... The IL-6 dependent HO-1 regulation in rat primary hepatocytes and HepG2 hepatoma cells was studied by Northern and Western blot analyses, HO-1 promoter reporter gene assays and EMSA ... The HO-1 expression was transcriptionally induced by IL-6 in a time- and dose dependent manner ... The HO-1 SBE3 mediates HO-1 gene induction by IL-6 mainly via activation of the Jak/STAT pathway
Pae et al., Inflamm Res 2007 : Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
Kamimoto et al., Int J Mol Med 2009 (Acute Disease...) : Using a mouse model of endotoxemia, we provide evidence to show that hepatocyte growth factor (HGF) enhances HO-1 expression in macrophages, thereby up-regulating IL-10 and down regulating IL-6 productions
Lee et al., Am J Pathol 2009 (Tracheitis) : In addition, HO-1 overexpression inhibited TNF-alpha induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression, adherence of THP-1 cells, generation of interleukin-6 , p47(phox) translocation, and nuclear factor-kappaB activation
Zou et al., Carcinogenesis 2011 (Liver Neoplasms...) : Interleukin (IL)-6 is one of the major downstream molecules that mediated this process because IL-6 expression and migration are suppressed by HO-1 and increased when HO-1 is knocked down by shRNA
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Lewkowicz et al., Immunobiology 2013 : We showed that LPS activated Treg cells promote generation of IL-10 and TGF-ß1, inhibit IL-6 production by PMNs and induce the expression of heme oxygenase-1 (HO-1) and the suppressor of cytokine signaling 3 molecule ( SOCS3 )
Lee et al., J Agric Food Chem 2013 (Diabetes Mellitus, Type 2) : It was found that monascin promoted heme oxygenase-1 (HO-1) expression mediated by Nrf2. Suppressions of AGEs, tumor necrosis factor-a (TNF-a), and interleukin-1ß ( IL-ß ) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid ( RA )
Collino et al., Dis Model Mech 2013 (Disease Models, Animal...) : Besides, chronic HO-1 activation suppressed the elevated levels of myeloperoxidase (MPO) activity, interleukin 1ß (IL-1ß) production and tumor necrosis factor-a (TNFa) production that were evoked by the ischemic injury, and increased the plasma level of the anti-inflammatory cytokine IL-10
Das et al., J Antimicrob Chemother 2013 (Leishmaniasis, Visceral) : Furthermore, HO-1 blockade by miltefosine led to suppression of interleukin-10 and transforming growth factor-ß, but enhanced interleukin-12 and tumour necrosis factor-a production, in VL patients