UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to ITGA2

ITGA2 — LAMB1

Pathways - manually collected, often from reviews:

KEGG Focal adhesion: CHAD/COL11A1/COL11A2/COL1A1/COL1A2/COL2A1/COL3A1/COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/COL5A1/COL5A2/COL5A3/COL6A1/COL6A2/COL6A3/COL6A6/COMP/FN1/IBSP/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3/RELN/SPP1/THBS1/THBS2/THBS3/THBS4/TNC/TNN/TNR/TNXB/VTN/VWF → Complex of 21 proteins (protein-protein, activation)
KEGG ECM-receptor interaction: LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA2-ITGB1 (protein-protein, activation)
KEGG Pathways in cancer: COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/FN1/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 (protein-protein, activation)
KEGG Small cell lung cancer: COL4A1/COL4A2/COL4A4/COL4A5/COL4A6/FN1/LAMA1/LAMA2/LAMA3/LAMA4/LAMA5/LAMB1/LAMB2/LAMB3/LAMB4/LAMC1/LAMC2/LAMC3 → Complex of ITGA2-ITGA2B-ITGA3-ITGA6-ITGAV-ITGB1 (protein-protein, activation)
NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 1 complex (LAMA1-LAMB1-LAMC1) → alpha2/beta1 Integrin complex (ITGA2-ITGB1) (modification, collaborate)
Lange et al., Exp Cell Res 1994, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 1 complex (LAMA1-LAMB1-LAMC1) → alpha2/beta1 Integrin/Laminin 1 complex (ITGA2-ITGB1-LAMA1-LAMC1-LAMB1) (modification, collaborate)
Lange et al., Exp Cell Res 1994, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha2/beta1 Integrin complex (ITGA2-ITGB1) → alpha2/beta1 Integrin/Laminin 1 complex (ITGA2-ITGB1-LAMA1-LAMC1-LAMB1) (modification, collaborate)
Lange et al., Exp Cell Res 1994, Calderwood et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 2 complex (LAMA2-LAMB1-LAMC1) → alpha2/beta1 Integrin/Laminin 2 complex (ITGA2-ITGB1-LAMA2-LAMC1-LAMB1) (modification, collaborate)
Colognato et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: Laminin 2 complex (LAMA2-LAMB1-LAMC1) → alpha2/beta1 Integrin complex (ITGA2-ITGB1) (modification, collaborate)
Colognato et al., J Biol Chem 1997
Evidence: physical interaction
NCI Pathway Database Beta1 integrin cell surface interactions: alpha2/beta1 Integrin/Laminin 2 complex (ITGA2-ITGB1-LAMA2-LAMC1-LAMB1) → alpha2/beta1 Integrin complex (ITGA2-ITGB1) (modification, collaborate)
Colognato et al., J Biol Chem 1997
Evidence: physical interaction
Reactome Reaction: ITGA2 → LAMB1 (indirect_complex)
Reactome Reaction: ITGA2 → LAMB1 (reaction)
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: COL4A2/CHAD/TNR/COL11A2/LAMB3/COMP/COL1A2/FN1/THBS2/COL5A1/RELN/LAMC3/LAMC2/LAMB1/COL4A6/TNC/COL5A2/LAMA4/COL4A1/LAMA3/LAMC1/LAMB2/THBS4/COL2A1/THBS3/LAMA5/IBSP/COL6A2/VWF/TNXB/TNN/SPP1/LAMA2/COL3A1/LAMA1/VTN/THBS1/COL1A1/COL11A1/COL5A3/COL4A4 → ITGA5/ITGAE/ITGAX/ITGAD/ITGA7/ITGA2B/ITGA9/ITGA2/PELO/ITGA3/ITGA8/ITGA10/ITGAV/ITGA6/ITGAL/ITGA4/ITGA11 (activation)