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EGF — PCBD1

Text-mined interactions from Literome

Fombonne et al., Mol Biol Cell 2004 : We show here that in somato-lactotrope pituitary cell line GH4C1, EGF triggers a PCD characterized by an apoptosis-like DNA fragmentation, insensitivity to broad-range caspase inhibitors, and absence of either cytochrome c or apoptosis inducing factor release from mitochondria ... Moreover, overexpression of cell death inhibitor Bcl-2 prevented not only the EGF induced PCD but also its prodifferentiation effects, thus pointing to a mechanistic relationship existing between these two phenomena
Abbott et al., J Craniofac Genet Dev Biol 1987 : In organ cultures of day 12 embryonic mouse palatal shelves, epidermal growth factor (EGF) blocks PCD , and DNA synthesis continues ... DNA synthesis in the medial cells was sustained and PCD was blocked by EGF , trans-RA, and 13-cis-RA