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CSF2 — TLR1
Text-mined interactions from Literome
Krutzik et al., Nat Med 2003
(Leprosy) :
In addition, interferon (IFN)-gamma and granulocyte-macrophage
colony stimulating factor ( GM-CSF )
enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression
Krutzik et al., Nat Med 2005
(Leprosy) :
CD1b+ dendritic cells were expanded by
TLR mediated upregulation of granulocyte-macrophage
colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
O'Mahony et al., International journal of medical sciences 2008
:
Of the cytokines examined, IFN-gamma and
GM-CSF caused the greatest effects on
TLR expression
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009
(Crohn Disease) :
In CD patients,
TLR induced
GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Fukuzono et al., Arch Biochem Biophys 2010
:
G-CSF and
GM-CSF did not
affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and
GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively
regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Nagoshi et al., J Immunol 1998
(Sarcoma, Experimental) :
This response was tumor specific since
TIL obtained from MCA-205 did not
induce high levels of IFN-gamma and
GM-CSF and did not induce tumor eradication of MCA-105 tumor