Yang et al., Clin Exp Pharmacol Physiol 2009
(Diabetes Mellitus, Experimental...) :
5. These results suggest that NADPH oxidase may play a potential role in oxidative stress induced arterial BH4 and GTP cyclohydrolase I deficiency, resulting in endothelial dysfunction in Ins2 ( Akita ) Type 1 diabetic mice fed a high-cholesterol diet
Xu et al., Hypertension 2009
(Hypertension) :
Genetic inhibition of NAD ( P ) H oxidase or administration of uric acid ( a peroxynitrite scavenger ) or N ( G ) -nitro-l-arginine methyl ester ( nonselective NO synthase inhibitor ) significantly attenuated Ang II-induced PA700 nitration, 26S proteasome activation, and reduction of GTP cyclohydrolase I and BH4