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AHSA1 — NOS2
Text-mined interactions from Literome
Ajizian et al., J Infect Dis 1999
:
Whether
p38 and extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase cascades are
required for
inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in RAW 264.7 murine macrophages exposed to lipopolysaccharide (LPS) plus recombinant interferon-gamma ( rIFN-gamma ) was investigated
Bellmann et al., J Biol Chem 2000
:
p38 dependent enhancement of cytokine induced
nitric-oxide synthase gene expression by heat shock protein 70
Jeon et al., J Pharmacol Exp Ther 2000
(MAP Kinase Signaling System) :
Collectively, this series of experiments indicates that radicicol
inhibits iNOS gene expression by blocking
p38 kinase signaling
Chan et al., Infect Immun 2001
:
By contrast, activated
p38mapk inhibited
iNOS induction
Liu et al., J Cell Biochem 2001
:
Distinct involvement of NF-kappaB and
p38 mitogen activated protein kinase pathways in serum deprivation
mediated stimulation of inducible
nitric oxide synthase and its inhibition by 4-hydroxynonenal
Monier et al., J Infect Dis 2002
:
The
role of
p38- and extracellular signal regulated kinase ( ERK ) mitogen activated protein ( MAP ) kinase pathways in the up-regulation of
inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) production in macrophages stimulated with Streptococcus pneumoniae was examined
Kan et al., Di Yi Jun Yi Da Xue Xue Bao 2002
:
To understand the
role of
p38 mitogen activated protein kinase ( p38MAPK ) in the expression of
inducible nitric oxide synthase (iNOS) and NO production in human endothelial cells under the stimulation by lipopolysaccharide (LPS)
Guo et al., Di Yi Jun Yi Da Xue Xue Bao 2003
:
To study the transcriptional
regulation of
inducible nitric oxide synthase (iNOS) gene by
p38 mitogen activated protein kinase ( MAPK )
Wang et al., J Neuroimmunol 2004
:
c-Jun N-terminal kinase and, to a lesser extent,
p38 mitogen activated protein kinase
regulate inducible
nitric oxide synthase expression in hyaluronan fragments stimulated BV-2 microglia
Chang et al., Kidney Int 2004
(MAP Kinase Signaling System) :
A protein tyrosine kinase inhibitor ( genistein ), or a
p38 mitogen activated protein kinase ( MAPK ) inhibitor ( SB203580 )
suppressed AGE induced
iNOS expression and nitrite release from mesangial cells
Gutiérrez-Venegas et al., Life Sci 2005
:
Role of
p38 in
nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides
Zhu et al., J Neurosci Res 2005
(Anoxia) :
Therefore, the attenuation of
p38 activation and
iNOS induction in hibernating and aroused animals may contribute to the attenuation of inflammation that plays important neuroprotective roles during hibernation
Makeeva et al., Biochem J 2006
:
The MKK3 potentiating effect on cytokine induced cell death was abolished by a
nitric oxide synthase inhibitor, and MKK3 stimulated
p38 phosphorylation was
enhanced by inhibitors of phosphatases
Schmidt et al., Biochem Pharmacol 2010
:
Inhibition of
p38MAPK , NF-kappaB and the JAK2-STAT-1alpha pathways
resulted in a reduction of
iNOS expression
Turpeinen et al., Mediators Inflamm 2011
:
iNOS expression was induced by a cytokine mixture ( TNF, IFN? and IL-1ß ) in A549 cells and by LPS in J774 cells, and it was
inhibited by
p38 MAPK inhibitors SB202190 and BIRB 796