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BTK — IRF6
Text-mined interactions from Literome
Jefferies et al., J Biol Chem 2003
:
Stimulation of the human monocytic cell line THP-1 with
LPS resulted in an increase in the level of tyrosine phosphorylation of
Btk ( indicative of activation ) ... Further investigation revealed that the
Btk-specific inhibitor, LFM-A13,
inhibited the activation of NFkappaB by
LPS in THP-1 cells
Horwood et al., J Exp Med 2003
(Agammaglobulinemia) :
Here we show that the Bruton's tyrosine kinase (Btk)-deficient mononuclear cells from X-linked agammaglobulinemia patients have impaired LPS induced TNF alpha production and that
LPS rapidly
induces Btk kinase activity in normal monocytes
Jefferies et al., Immunol Lett 2004
:
Further investigation into the
role of
Btk in
LPS signalling has directly implicated Btk downstream of TLR4, both with respect to p38 MAPK activation and activation of the transcription factor NFkappaB ... In fact
Btk is
activated by
LPS and has been shown to directly bind TLR4 and the key proximal signalling proteins involved in LPS induced NFkappaB activation, MyD88, Mal and IRAK-1 ... These recent findings point to a direct role for Btk in LPS signal transduction and raise interesting questions regarding the mode of
activation of
Btk following
LPS stimulation and the precise nature of the pathways activated downstream of Btk
Horwood et al., J Immunol 2006
:
Bruton's tyrosine kinase (Btk) , the gene mutated in the human immunodeficiency X-linked agammaglobulinemia, is
activated by
LPS and is required for LPS induced TNF production
Pérez de Diego et al., J Allergy Clin Immunol 2006
(Agammaglobulinemia...) :
Our results indicate that
Btk is not
essential for early
LPS signaling in human monocytes and that different Btk dependency might exist between human and mouse myeloid cells
Khandaker et al., J Immunol 1998
:
The tyrosine kinase ( TK ) inhibitors genistein and herbimycin A attenuated the LPS mediated down-modulation of CXCR1 and CXCR2, indicating that the activation of
a TK is
required for
LPS to mediate its effect