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BTK — IL12A
Text-mined interactions from Literome
Hasan et al., Immunology 2008
:
In this study we set out to investigate the potential
role of
Btk in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6, tumour necrosis factor (TNF)-alpha and
IL-12p40
Lee et al., J Biol Chem 2008
:
The addition of exogenous recombinant IL-10 could suppress IL-12 production by TLR9 activated Btk ( -/- ) B cells, suggesting that in B cells,
Btk negatively
regulates IL-12 through the induction of autocrine IL-10 production ... Thus,
Btk plays an important role in TLR9 signaling and acts separately to
regulate NFkappaB RelA activation as well as IL-10 and
IL-12 production in B cells