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MDM2 — NEDD8

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: NEDD8 (NEDD8) → MDM2 (MDM2) (modification, collaborate) Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: MDM2 (MDM2) → p53/NEDD8 complex (TP53-NEDD8) (modification, activates)
  Xirodimas et al., Cell 2004*
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — NEDD8 (physical association, affinity chromatography technology) Xirodimas et al., Cell 2004*
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012

Text-mined interactions from Literome

Singh et al., J Biol Chem 2007 : Furthermore, we show that, similar to Mdm2, the Mdm2-MdmX complex has Nedd8 ligase activity and that all mutations that affect the ubiquitin ligase activity of Mdm2 also affect its Nedd8 ligase activity
Dohmesen et al., Cell cycle (Georgetown, Tex.) 2008 : We found that Tip60 is capable of selectively inhibiting the Mdm2 mediated conjugation of Nedd8 to p53, whereas it did not affect p53 ubiquitination