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Karim et al., Mol Cell 1999
:
Ectopic expression of PTP-ER dramatically inhibits RAS1/MAPK signaling
Egawa et al., J Biol Chem 2001
(Carcinoma, Hepatocellular...) :
In both cells, PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 by more than 70 % and resulted in a significant inhibition of the association between IRS-1 and the p85 subunit of phosphatidylinositol 3-kinase and Akt phosphorylation as well as mitogen activated protein kinase phosphorylation
Khoutorsky et al., Learn Mem 2009
(Calcium Signaling) :
Inhibition of CaM kinases, PKA, and MAPK also reduced PTP at this synapse