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BMP2 — SMN1
Text-mined interactions from Literome
Yamamoto et al., Endocrinology 2002
:
BMP-2 induced activation of
Sma and Mad ( mothers against decapentaplegic ) -related protein ( Smad ) activity and BMP-2 mediated gene expression were suppressed by 17beta-E2 in breast cancer cells and mesangial cells
Warming et al., Blood 2003
(Lymphoma, B-Cell) :
EBFAZ also binds to
SMA- and MAD related protein-1 (SMAD1) and SMAD4 in
response to
bone morphogenetic protein-2 (BMP2) signaling, which in turn activates the homeobox regulator of Xenopus mesoderm and neural development Xvent-2
Warming et al., Oncogene 2004
(Lymphoma...) :
It also binds to
SMA- and MAD related protein 1 (SMAD1) and SMAD4 in
response to
bone morphogenic protein 2 (BMP2) signaling
Chalazonitis et al., J Neurosci 2004
:
When applied to immunopurified E12 ENS precursors,
BMP-2 and BMP-4
induced nuclear translocation of phosphorylated Smad-1 (
Sma and Mad related protein )
Matsui et al., Dev Growth Differ 2008
:
During heart development at the gastrula stage, inhibition of
bone morphogenetic protein ( BMP ) activity affects the heart specification but does not
impair the expression of
smooth muscle alpha-actin (SMA) , which is first expressed in the heart mesoderm and recruited into initial heart myofibrils
Wang et al., Stem Cells Dev 2012
:
Exploring the molecular basis for this effect, we found that restricting cell spreading, reducing ROCK signaling, or inhibiting cytoskeletal tension prevented
BMP induced
SMA/mothers against decapentaplegic ( SMAD)1 c-terminal phosphorylation, SMAD1 dimerization with SMAD4, and SMAD1 translocation into the nucleus
Gao et al., Am J Physiol Gastrointest Liver Physiol 2013
(Fibrosis...) :
Knocking down Smad1 with small interfering RNA reversed the inhibitory
effect of
BMP2 on TGF-ß induced
a-SMA and fibronectin expression
McCormack et al., Respir Res 2013
:
Exogenous
BMP2 , BMP4 and BMP7
induced a mesenchymal-like morphology in AECs, enhanced the rate of cell migration and increased
a-SMA protein expression in AECs