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CDH5 — SLC22A3
Text-mined interactions from Literome
Timmerman et al., Genes Dev 2004
(Cell Transformation, Neoplastic) :
Overexpression of N1IC in immortalized endothelial cells in vitro
induces EMT accompanied by oncogenic transformation, with corresponding induction of snail and repression of
VE-cadherin expression
Wendt et al., Oncogene 2010
(Breast Neoplasms...) :
Mechanistically,
EMT induced by TGF-ß increased cell-surface levels of EGFR and
prevented its physical interaction with
E-cadherin , leading instead to the formation of oncogenic signaling complexes with TßR-II
von Gise et al., Dev Biol 2011
:
Although Wt1 has been proposed to
regulate EMT by repressing
E-cadherin , we detected no change in E-cadherin in Wt1 ( KO ) epicardium
Park et al., Dev Biol 2012
:
Importantly, LIMK1 as well as cadherin-6B can trigger ectopic delamination when co-expressed with the competence factor SOX9, showing that this
cadherin-6B stimulated signaling pathway can
mediate the full
EMT in the appropriate context