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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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SLC22A3 — TLR4

Text-mined interactions from Literome

Jing et al., BMC medicine 2012 (Carcinoma, Hepatocellular) : The in vitro and in vivo experiments demonstrated that LPS could significantly enhance the invasive potential and induce EMT in HCC cells with TLR4 dependent ... Our results indicate that TLR4 signaling is required for LPS induced EMT , tumor cell invasion and metastasis, which provide molecular insights for LPS related pathogenesis and a basis for developing new strategies against metastasis in HCC
Liu et al., Lab Invest 2013 (Adenocarcinoma...) : Activation of TLR4 on M2-polarized TAMs stimulates an increase in the cytokine interleukin-10 (IL-10) ; consequently, another aim was to investigate the potential role of TLR4/IL-10 signaling in the EMT of pancreatic cancer ... Furthermore, activation of TLR4 signaling by lipopolysaccharide profoundly increased the EMT of pancreatic cancer cells