◀ Back to PIK3R1
PIK3R1 — RAC3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Nosaka et al., Biochem Biophys Res Commun 2001
(Fibrosarcoma) :
The
PI3K inhibitor LY294002 significantly
inhibited TNFalpha activation of
Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation
Kanda et al., Biochem Biophys Res Commun 2003
:
These results implicate CrkL in
PI3K dependent activation of
Rac by outside-in signaling from alpha4beta1 and suggest that adhesion through alpha4beta1 further activates cytokine receptor associated Jak2 to induce phosphorylation of these receptors
Welch et al., FEBS Lett 2003
(Second Messenger Systems) :
Vice versa,
Rac can also
stimulate the activation of
PI3K , although the mechanism for this is unclear
Alahari et al., Exp Cell Res 2003
:
Furthermore, Nischarin does not affect
Rac mediated JNK and
PI3K activities
Sánchez-Martín et al., J Biol Chem 2004
:
We have identified Vav, a guanine nucleotide exchange factor for Rac-1, and PI3K/Akt, as regulators of the activation and inactivation phases of the activity of Rac-1, respectively, in the context of LFA-1 signaling based on the following experimental evidence : ( i ) LFA-1 induced activation of Vav and
PI3K/Akt with kinetics consistent with a regulatory role for these molecules on Rac-1, ( ii ) overexpression of a constitutively active Vav mutant induces activation of Rac independently of LFA-1 stimulation whereas overexpression of a dominant negative Vav mutant
blocks LFA-1 mediated
Rac activation, ( iii ) pharmacological inhibition of PI3K/Akt prevented the fall in the activity of Rac-1 after its initial activation but had no effect on Vav activity, and ( iv ) overexpression of a dominant negative or a constitutively active Akt-1 induced or inhibited, respectively, Rac-1 activity
Felekkis et al., Mol Cancer Res 2005
(Breast Neoplasms) :
Inhibition of
PI3K with LY294002 or a dominant negative p85 construct
blocked AND-34 mediated
Rac and Akt activation ... Our studies suggest that AND-34 mediated
PI3K activation
induces Rac activation and anti-estrogen resistance in human breast cancer cell lines
Gouëffic et al., Cardiovasc Res 2006
:
Hyaluronan induces vascular smooth muscle cell migration through RHAMM mediated
PI3K dependent
Rac activation ... HA-induced migration depends exclusively on RHAMM mediated
PI3K dependent
Rac activation
Vanni et al., Cell cycle (Georgetown, Tex.) 2006
:
Inhibition of
PI3K induces
Rac activation and membrane ruffling in proto-Dbl expressing cells
Nielsen-Preiss et al., Endocrinology 2007
:
In addition,
PI3K inhibition in GnRH neuronal cells
diminished Gas6 induced
Rac activation
Nizhynska et al., Dev Neurobiol 2007
:
Moreover, agrin induced activation of
Rac and Cdc42 is
impaired in the presence of
PI3-K inhibitors
Samaga et al., PLoS Comput Biol 2009
(Liver Neoplasms) :
Our results strongly suggest that the
Rac/Cdc42 induced p38 and JNK cascades are
independent of
PI3K in both primary hepatocytes and HepG2