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EGF — FST
Text-mined interactions from Literome
Michel et al., J Mol Endocrinol 1992
:
Activin raised basal as well as FSH stimulated steady-state follistatin mRNA levels up to ten- and twofold above controls respectively, whereas
epidermal growth factor was found to
inhibit FSH stimulated
follistatin mRNA levels in a dose dependent manner ... It is concluded that
follistatin mRNA levels in granulosa cells are regulated by FSH rather than LH, and that the stimulation by FSH can be
inhibited by
epidermal growth factor but enhanced by activin
Bearfield et al., Eur J Endocrinol 2005
:
Secretion of inhibin A, activin A and
follistatin in the
presence of
EGF , IL-1beta, activin A and follistatin were measured using in-house ELISAs
Lindsell et al., Endocrine 1995
:
Results in the longer term differed, as pretreatment of granulosa cells with CHX for 20 h suppressed the
induction of
follistatin gene expression by both
EGF and phorbol 12-myristate-13-acetate
Lindsell et al., Endocrinology 1993
:
EGF ( 0.01, 0.1, 1, and 10 nM )
induced a dose dependent induction of
follistatin gene expression in granulosa cells after 2-h incubation, with maximal stimulation of 33-fold at a dose of 1 nM ... Pretreatment of granulosa cells for 24 h with PMA abrogated the
EGF induced stimulation of
follistatin mRNA accumulation ... These results demonstrate that 1 )
follistatin gene expression in cultured porcine granulosa cells is acutely
stimulated by PMA and
EGF in a time- and dose dependent manner ; 2 ) follistatin gene expression may be regulated by the PKC pathway ; and 3 ) the stimulatory effect of EGF on follistatin gene expression may require PKC
Zhang et al., Hepatology 1996
:
EGF augmented the release of
follistatin , an activin binding protein known to block the action of activin A, by hepatocytes and NE did not affect the amount of follistatin they released