UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to TYK2

IL27RA — TYK2

Pathways - manually collected, often from reviews:

NCI Pathway Database IL27-mediated signaling events: STAT1 (STAT1) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
NCI Pathway Database IL27-mediated signaling events: IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (transcription, activates)
Chen et al., Nature 2000, Yoshida et al., Immunity 2001, Pflanz et al., Immunity 2002, Kamiya et al., J Immunol 2004
Evidence: mutant phenotype, other species
NCI Pathway Database IL27-mediated signaling events: STAT5A (STAT5A) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
NCI Pathway Database IL27-mediated signaling events: IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2) → IL27/EBI3 complex (IL27-EBI3) (modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
NCI Pathway Database IL27-mediated signaling events: IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
NCI Pathway Database IL27-mediated signaling events: IL27/EBI3 complex (IL27-EBI3) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Pflanz et al., J Immunol 2004
Evidence: functional complementation
NCI Pathway Database IL27-mediated signaling events: STAT3 (STAT3) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species
NCI Pathway Database IL27-mediated signaling events: STAT2 (STAT2) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
NCI Pathway Database IL27-mediated signaling events: STAT4 (STAT4) → IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3) (modification, collaborate)
Lucas et al., Proc Natl Acad Sci U S A 2003
Evidence: mutant phenotype, other species