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GRB2 — IL21

Text-mined interactions from Literome

Lee et al., Phytother Res 2013 (Inflammation) : GRb1 significantly reduced the upregulation of tumor necrosis factor-a, interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection
Lindner et al., Cancer Res 2013 (Neoplasms) : Mechanistic investigations into how IL-21 induced GrB expression in B cells to confer Breg function revealed a CD19 ( + ) CD38 ( + ) CD1d ( + ) IgM ( + ) CD147 ( + ) expression signature, along with expression of additional key regulatory molecules including IL-10, CD25, and indoleamine-2,3-dioxygenase ... Notably, induction of GrB by IL-21 integrated signals mediated by surface immunoglobulin M ( B-cell receptor ) and Toll-like receptors, each of which were enhanced with expression of the B-cell marker CD5 ... Our findings show for the first time that IL-21 induces GrB ( + ) human Bregs