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BBS2 — PTGS2

Text-mined interactions from Literome

Guo et al., Dig Dis Sci 2008 : BBS , but not TGF-beta1, stimulated COX-2 promoter activity, and TGF-beta1 enhanced COX-2 mRNA stability through a p38 ( MAPK ) -dependent pathway ... The synergistic regulation of COX-2 expression by TGF-beta1 and BBS may contribute to the upregulation of COX-2 in GI cancers
Wen et al., BMC molecular biology 2011 (Prostatic Neoplasms) : BBS stimulated COX-2 expression is mediated, in part, by p38MAPK and PI3 kinase (PI3K)/Akt pathways, and blocked by a GRPR antagonist ... The p38MAPK pathway increases BBS stimulated COX-2 expression by slowing the degradation of COX-2 mRNA ... Expression of recombinant GRPR in the androgen-sensitive cell line LNCaP is sufficient to confer BBS stimulated COX-2 expression via the p38MAPK and PI3K/Akt pathways