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GSTA1 — IL1B

Text-mined interactions from Literome

Romero et al., Drug Metab Dispos 2002 : Deletion of a hepatic nuclear factor 1 ( HNF-1 ) site in this region abrogated the IL-1beta mediated repression of GSTA1 promoter activity
Ng et al., Mol Pharmacol 2007 : Repression of human GSTA1 by interleukin-1beta is mediated by variant hepatic nuclear factor-1C ... We investigated the role of hepatic nuclear factor 1 ( HNF-1 ) in repression of human GSTA1 expression by interleukin (IL)-1beta in Caco-2 cells ... IL-1beta reduced GSTA1 mRNA levels at all stages of confluence ; however, HNF-1alpha mRNA levels were not altered ... IL-1beta repressed GSTA1 transcriptional activity, an effect that was abolished by mutating the HRE ... Overexpression of HNF-1alpha did not counteract IL-1beta mediated repression of GSTA1 transcription either in reporter assays or at the mRNA level ... These findings indicate that IL-1beta represses GSTA1 transcription via a mechanism involving overexpression of vHNF-1C