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CCND3 — E2F1

Pathways - manually collected, often from reviews:

• BioCarta cyclins and cell cycle regulation: RB/E2F-1 complex (E2F1-RB1) → CDK6/cyclin D3 complex (CDK6-CCND3) (modification, collaborate)
  
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → Cyclin D3 (CCND3) (transcription, activates) Ma et al., J Biol Chem 2003, Wang et al., J Biol Chem 2007
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Ma et al., J Biol Chem 2003 : Regulation of the cyclin D3 promoter by E2F1
Hong et al., Cell Physiol Biochem 2012 : Then we determined the effects of KLF15 and its downstream target, cell cycle regulation factor E2F1 on the proliferation of mesangial cells and the expression of the positive acting cell cycle regulatory proteins, cyclinD1 and CDK2, by means of positive and negative interference experiments in cultured rat mesangial cells