◀ Back to TRAF6
IL1R1 — TRAF6
Pathways - manually collected, often from reviews:
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IL-1-alpha (IL1A)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6)
(modification, collaborate)
-
BioCarta nf-kb signaling pathway:
IL-1-alpha (IL1A)
→
IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
TRAF6
(modification, activates)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
TAB1/TAK1 complex (MAP3K7IP1-MAP3K7)
(modification, activates)
-
BioCarta nf-kb signaling pathway:
IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
-
KEGG Osteoclast differentiation:
IL1R1
→
TRAF2/TRAF6
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
IL1R1/IL1R2
→
TRAF6
(protein-protein, indirect effect)
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
TRAF6 (TRAF6)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IRAK/TRAF6 complex (IRAK1-TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4)
(modification, collaborate)
Bin et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, activates)
Bin et al., J Biol Chem 2003
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
IL1R1
→
TRAF6
(reaction)
Gottipati et al., Cell Signal 2008, Cao et al., Nature 1996
-
Reactome Reaction:
IL1R1
→
TRAF6
(indirect_complex)
Cao et al., Nature 1996
-
WikiPathways MAPK Signaling Pathway:
IL1R2/IL1R1
→
TRAF6
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IL1R1
—
TRAF6
(physical association, affinity chromatography technology)
Jiang et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
IL1R1
—
TRAF6
(physical association, affinity chromatography technology)
Jiang et al., Mol Cell Biol 2002
-
IRef Biogrid Interaction:
IL1R1
—
TRAF6
(physical association, affinity chromatography technology)
Jiang et al., J Biol Chem 2003
-
IRef Biogrid Interaction:
IL1R1
—
TRAF6
(direct interaction, enzymatic study)
Elzinga et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
IL1R1
—
TRAF6
(physical association, affinity chromatography technology)
Rafferty et al., Immunol Invest 2010*
-
IRef Innatedb Interaction:
IL1R1
—
TRAF6
(unknown, -)
Schmitz et al., Immunity 2005*
-
IRef Innatedb Interaction:
IL1R1
—
TRAF6
(unknown, -)
Jiang et al., Mol Cell Biol 2002
-
IRef Innatedb Interaction:
IL1R1
—
TRAF6
(unknown, -)
Jiang et al., J Biol Chem 2003
-
IRef Innatedb Interaction:
IL1R1
—
TRAF6
(unknown, -)
Li et al., Mol Cell Biol 2006*
-
IRef Intact Interaction:
Complex of TRAF6-IL1R1-MAP3K14
(association, anti bait coimmunoprecipitation)
Li et al., J Biol Chem 2006*
-
IRef Intact Interaction:
IL1R1
—
TRAF6
(physical association, anti bait coimmunoprecipitation)
Li et al., J Biol Chem 2006*
Text-mined interactions from Literome
Wang et al., Nat Immunol 2006
:
Association of beta-arrestin and
TRAF6 negatively
regulates Toll-like
receptor-interleukin 1 receptor signaling
Chen et al., Cell Signal 2008
:
Syntenin negatively regulates
TRAF6 mediated
IL-1R/TLR4 signaling
Chantzoura et al., Biochem Biophys Res Commun 2010
:
Taken together, our findings reveal another signalling molecule affected by S-glutathionylation and uncover a crucial role for GRX-1 in the
TRAF6 dependent activation of NF-?B by
IL-1R/TLRs