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NOTCH1 — PTEN

Text-mined interactions from Literome

Whelan et al., Cell cycle (Georgetown, Tex.) 2007 : In a previous study, we found that Notch-1 signaling resulted in increased PTEN protein expression
Palomero et al., Nat Med 2007 (Disease Models, Animal...) : Here we show that NOTCH1 regulates the expression of PTEN ( encoding phosphatase and tensin homolog ) and the activity of the phosphoinositol-3 kinase (PI3K)-AKT signaling pathway in normal and leukemic T cells
Silva et al., Haematologica 2010 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia : rationale for combined use of CK2- and gamma-secretase inhibitors
Liu et al., Urol Oncol 2013 (Carcinoma, Renal Cell...) : Blocking NOTCH1 signaling resulted in the attenuation of proliferation, invasion, and migration, as well as PTEN up-regulation with decreased AKT phosphorylation ... Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that NOTCH1 could regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines
Pei et al., Basic Res Cardiol 2013 (Myocardial Reperfusion Injury) : Moreover, Notch1 blockade also reduced phosphorylation of endothelial NO synthase (eNOS) and Akt, and increased expression of PTEN , a key phosphatase involved in the regulation of Akt phosphorylation