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MYC — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bowman et al., Proc Natl Acad Sci U S A 2001
(Cell Transformation, Neoplastic) :
Stat3 mediated
Myc expression is required for Src transformation and PDGF induced mitogenesis ... We show here that disruption of
Stat3 signaling by using dominant negative Stat3beta protein in NIH 3T3 fibroblasts
suppresses c-Myc expression concomitant with inhibition of v-Src induced transformation ... Ectopic expression of c-Myc is able to partially reverse this inhibition, suggesting that
c-Myc is a downstream
effector of
Stat3 signaling in v-Src transformation
Mamidipudi et al., Mol Cell Biol 2004
(Neoplasms) :
We also show that
Stat3 is
required for Rac1 induction of
Myc
Delgado et al., Dig Dis Sci 2008
(Adenocarcinoma...) :
This drug significantly reduced the up-regulations of cyclin D1, cyclin E,
c-Myc , and Bcl-2 as well as the
activation of
STAT3 in SEG-1 cells
Han et al., Molecular cancer 2010
(Disease Models, Animal...) :
Inhibition of
STAT3 signaling eliminated the activity of both NF-kappaB and Myc, and
resulted in a corresponding decrease in the level of
Myc
Zhang et al., Proc Natl Acad Sci U S A 2012
(Breast Neoplasms...) :
BP-1-102 mediated inhibition of aberrantly active
Stat3 in tumor cells
suppresses the expression of
c-Myc , Cyclin D1, Bcl-xL, Survivin, VEGF, and Krüppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3 mediated breast tumor cell migration and invasion
David et al., Am J Pathol 2012
(Bone Neoplasms...) :
Knockdown experiments demonstrated that growth induction by OSM depends on both types I [leukemia inhibitory factor receptor ( LIFR ) ] and II [OSM receptor ( OSMR ) ] receptors, high
STAT3 activation , and induction of
MYC to a high expression level