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BDNF — RAC1
Text-mined interactions from Literome
Noga et al., Clin Exp Allergy 2007
(Hypersensitivity) :
NGF led to decreased RhoA and increased Rac activation, while
BDNF affected RhoA and
Rac activity in a reciprocal fashion
Namekata et al., Proc Natl Acad Sci U S A 2010
:
BDNF induces axonal sprouting through Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Lindsley et al., Alcohol Clin Exp Res 2011
:
In contrast, ethanol exposure inhibited
BDNF induced
Rac1/Cdc42 activation in a dose dependent manner and increased RhoA activation at the highest concentration tested
Hale et al., J Neurosci 2011
:
We find that Vav is required for
BDNF stimulated
Rac-GTP production in cortical and hippocampal neurons
Mullen et al., Brain Res 2012
(MAP Kinase Signaling System) :
Activation of
Rac/cdc42/JNK signaling by
BDNF may reduce the formation of neurites
Tep et al., J Biol Chem 2012
:
Here we report that Par3 regulates
Rac1 activation by
BDNF but not by NRG1-Type III in Schwann cells, although both ligands activate Rac1 in vivo
Imam et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
Our results reveal that loss of miR-204 results in
BDNF overexpression and subsequent
activation of the small GTPase
Rac1 and actin reorganization through the AKT/mTOR signaling pathway leading to cancer cell migration and invasion
Li et al., J Neurochem 2013
:
In addition, GGT and its known substrate
Rac was
activated by
BDNF , which promotes synaptogenesis in cultured hippocampal neurons