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IL3 — ODC1

Text-mined interactions from Literome

Farrar et al., Lymphokine Cytokine Res 1991 : However, PK-C down-regulation had a pronounced inhibitory effect on IL-3 regulation of ODC enzymatic activity
Ghigo et al., J Cell Physiol 1990 : Both IL-3 and GM-CSF induce in M-07e cells an increase of ornithine decarboxylase (ODC) activity, which reaches its maximum at 24-30 h and fully depends on de novo protein synthesis
Packham et al., Oncogene 1997 : Here we demonstrate that regulation of ODC and its promoter by Interleukin-3 (IL-3) in murine myeloid cells is mediated in part by c-Myc, c-Myc induced ODC through the same transcription start site as IL-3 and, in asynchronously growing cells, maximal activity of the ODC promoter required the intronic c-Myc binding sites ... Consistent with a two pathway model of ODC regulation, inducible overexpression of dominant negative form of c-Myc ( In373-Myc ), which specifically inhibits the c-Myc-Max network, inhibited the delayed, but not immediate, induction of ODC promoter activity in response to IL-3 ... Dominant negative c-Myc protein also effectively suppressed induction of the endogenous ODC gene by IL-3