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COA4 — EGFR

Text-mined interactions from Literome

Moore et al., PloS one 2012 (Hypercalcemia...) : MT19c reduced cellular levels of malonyl CoA in SKOV-3 cells and inhibited EGFR/phosphoinositol-3kinase (PI-3K) activity independently of PPAR-gamma protein
Orellana et al., Eur J Biochem 1993 : However, in vitro experiments showed that protein-kinase-C phosphorylation of purified epidermal-growth-factor receptor was activated by ciprofibroyl-CoA , the acyl-CoA derivative of the drug, but not by the unmodified drug