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NOD2 — TNF
Text-mined interactions from Literome
Gutierrez et al., J Biol Chem 2002
(Crohn Disease...) :
Notably, stimulation of myeloblastic and epithelial cells with bacterial lipopolysaccharide or
TNFalpha resulted in up-regulation of
Nod2 ... Upon
stimulation with
TNFalpha or lipopolysaccharide, both p50 and p65 subunits of NF-kappaB were bound to the
Nod2 promoter
Rosenstiel et al., Gastroenterology 2003
:
TNF-alpha and IFN-gamma
regulate the expression of the
NOD2 ( CARD15 ) gene in human intestinal epithelial cells ...
TNF-alpha induced an up-regulation of
NOD2 in epithelial cell lines ( HT-29, SW620, SW948, HeLa S3 ) and in primary colonic epithelial cells
Iwanaga et al., Inflamm Res 2003
(Arthritis...) :
NOD2 mRNA levels increased greater than two-fold in a monocyte cell line in
response to lipopolysaccharide, lipoteichoic acid, interferon-g and
tumor necrosis factor-alpha
Linderson et al., Int J Colorectal Dis 2005
(Crohn Disease...) :
We sought to determine whether
CARD15 mediated NF-kappaB activation can
contribute to MDP induced
TNFalpha production and, consequently, if polymorphisms in both genes affect the control of such induction ... Transfection and electrophoretic mobility shift assays ( EMSA ) experiments in HEK293 cells demonstrated that MDP exposure stimulates TNFalpha gene transcription, as a result of
CARD15 induced NF-kappaB activation and binding to
TNFalpha promoter
Yang et al., J Immunol 2005
:
Induction of
Nod2 mRNA expression by LPS but not by
TNF-alpha in osteoblasts was dependent on TLR4 and MyD88
Yamashita et al., Nihon rinsho. Japanese journal of clinical medicine 2005
:
Osteoblasts express
NOD2 , an intracellular sensor for MDP, in
response to LPS, IL-1 and
TNF
Oh et al., Cell Immunol 2005
:
Human umbilical vascular endothelial cells ( HUVECs ) minimally expressed NOD2 gene, whereas stimulation of HUVEC with bacterial LPS, IL-1beta, or
TNF-alpha resulted in significant up-regulation of
NOD2
Yamashita et al., Clinical calcium 2006
:
Osteoblasts express
nucleotide oligomerization domain (NOD)2 , an intracellular sensor for MDP, in
response to LPS, IL-1 and
TNF
Gandotra et al., Infect Immun 2007
(Tuberculosis) :
Mycolylarabinogalactan peptidoglycan ( PGN ), the cell wall core of M. tuberculosis, stimulated macrophages to release tumor necrosis factor (TNF) and interleukin-12p40 in a partially NOD2 dependent manner, and M. tuberculosis PGN
required NOD2 for the optimal induction of
TNF
Farkas et al., Scand J Immunol 2008
:
Our study provides evidence that
NOD2 , toll-like receptor 4 (TLR4) and the adapter protein receptor interacting protein 2 (RIP2) are
induced by
tumor-necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in the bronchial epithelial cell line BEAS-2B
Wikén et al., J Clin Immunol 2009
(Sarcoidosis) :
Combined TLR2 and
NOD2 stimulation
induced a four-fold higher secretion of
TNFalpha and a 13-fold higher secretion of IL-1 beta in patients
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009
(Crohn Disease) :
CD patients have impaired GM-CSF secretion via NOD2 dependent and -independent pathways and display an impaired
NOD2 dependent down-regulation of
TNF-alpha secretion
Coulombe et al., J Exp Med 2009
:
Disruption of namH in Mycobacterium smegmatis obrogated
NOD2 mediated
TNF secretion, which could be restored upon gene complementation
van Hoffen et al., Int Arch Allergy Immunol 2010
:
Apically added LGG, TLR2 and
NOD2 ligands, but not Bb,
enhanced IFN-gamma, IL-12 and/or
TNF-alpha secretion
Hosokawa et al., J Periodontal Res 2010
(Chronic Periodontitis...) :
TNF-alpha and IFN-gamma
increased NOD2 expression in HGFs
Jiang et al., Int Immunopharmacol 2011
(Sepsis...) :
Artesunate not only inhibited
TNF-a and IL-6 release but also
inhibited mRNA and protein expressions of TLR2 and
Nod2 , two important receptors, in murine peritoneal macrophages stimulated with heat killed WHO-2, further demonstrating anti-inflammatory effect of artesunate was related to the inhibition of TLR2- and Nod2 mediated proinflammatory cytokines
de Jong et al., PLoS Pathog 2012
(Salmonella Infections...) :
The interaction of Salmonella pathogen associated molecular patterns ( PAMPs ) with Toll-like receptors ( TLRs ) and
NOD-like receptors ( NLRs ) leads to inflammasome formation, activation, and recruitment of neutrophils and macrophages and the production of pro-inflammatory cytokines, most notably interleukin (IL)-6, IL-1ß,
tumor necrosis factor (TNF)-a , and interferon-gamma (IFN)-?
Jamontt et al., J Immunol 2013
(Chronic Disease...) :
However, loss of
NOD2 in IL-10-deficient macrophages
reduced IL-6,
TNF-a , and IL-12p40 production in response to bacterial stimulation
Park et al., PloS one 2013
:
Here, we show that p62 positively regulates
NOD2 induced NF-?B activation and p38 MAPK, and subsequent production of cytokines IL-1ß and
TNF-a